源自六异戊二烯基焦磷酸的一类新型三萜的发现与分析。
Discovery and analysis of a new class of triterpenes derived from hexaprenyl pyrophosphate.
作者信息
Hu Dan
机构信息
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy / Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research / International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou 510632, China.
出版信息
Eng Microbiol. 2022 Jul 8;2(3):100035. doi: 10.1016/j.engmic.2022.100035. eCollection 2022 Sep.
Triterpenes are derived from squalene or oxidosqualene. However, a new class of triterpenes derived from hexaprenyl pyrophosphate has been recently discovered, formed by a new family of chimeric class I triterpene synthases. The cyclization mechanisms of triterpenes were elucidated by isotopic labeling and protein structural analyses, which helps understand the biosynthesis of triterpenes in nature.
三萜类化合物由角鲨烯或氧化角鲨烯衍生而来。然而，最近发现了一类由六异戊二烯基焦磷酸衍生的新型三萜类化合物，它们由一个嵌合的I类三萜合酶新家族形成。通过同位素标记和蛋白质结构分析阐明了三萜类化合物的环化机制，这有助于理解自然界中三萜类化合物的生物合成。
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