Friedman G D, Blaner W S, Goodman D S, Vogelman J H, Brind J L, Hoover R, Fireman B H, Orentreich N
Am J Epidemiol. 1986 May;123(5):781-9. doi: 10.1093/oxfordjournals.aje.a114307.
Retinol and retinol-binding protein levels were measured in sera previously obtained, and stored in the frozen state, at multiphasic health checkups from 151 persons subsequently found to have lung cancer (cases) and 302 persons who remained free of cancer (controls). Two controls were matched to each case for sex, skin color, age, date of multiphasic health checkup, and aspects of the smoking habit. Mean levels in cases and controls were, respectively, retinol: 82.17 and 82.37 micrograms/dl (p = 0.93), and retinol-binding protein: 6.04 and 6.00 mg/dl (p = 0.81). Mean differences between cases and controls were, retinol: 0.195 micrograms/dl with 95% confidence limits, -3.91 and 4.30 micrograms/dl; retinol-binding protein: -0.033 mg/dl with 95% confidence limits, -0.31 and 0.24 mg/dl. No significant trend in relative risk of lung cancer was observed when the retinol or retinol-binding protein distribution was divided into quintiles. No significant associations were observed in subgroups based on age, sex, histologic type of cancer, cigarette consumption, or interval between blood drawing and cancer diagnosis. In this large study, retinol and retinol-binding protein levels were not useful in predicting the subsequent development of lung cancer.
对先前采集并冷冻保存的血清进行检测，测定了151例后来被诊断为肺癌的患者（病例组）和302例未患癌症的人（对照组）在多阶段健康检查时的视黄醇和视黄醇结合蛋白水平。为每例病例匹配两名性别、肤色、年龄、多阶段健康检查日期及吸烟习惯方面相匹配的对照。病例组和对照组的平均水平分别为：视黄醇：82.17和82.37微克/分升（p = 0.93），视黄醇结合蛋白：6.04和6.00毫克/分升（p = 0.81）。病例组与对照组的平均差异为：视黄醇：0.195微克/分升，95%置信区间为-3.91至4.30微克/分升；视黄醇结合蛋白：-0.033毫克/分升，95%置信区间为-0.31至0.24毫克/分升。当视黄醇或视黄醇结合蛋白分布分为五分位数时，未观察到肺癌相对风险的显著趋势。在根据年龄、性别、癌症组织学类型、香烟消费量或采血与癌症诊断之间的间隔划分的亚组中，未观察到显著关联。在这项大型研究中，视黄醇和视黄醇结合蛋白水平无助于预测随后肺癌的发生。
