维生素A、锌与肺癌
Vitamin A, zinc and lung cancer.
作者信息
Atukorala S, Basu T K, Dickerson J W, Donaldson D, Sakula A
出版信息
Br J Cancer. 1979 Dec;40(6):927-31. doi: 10.1038/bjc.1979.287.
Abstract
Serum vitamin A concentration were measured in 26 newly diagnosed lung-cancer patients and found to be significantly lower than those of patients of similar age with either non-malignant lung or non-lung diseases. The levels of vitamin A in the lung-cancer patients, but not in the controls, were significantly correlated with serum concentrations of retinol-binding protein (RBP) and zinc. It is suggested that low levels of zinc might reduce the synthesis of RBP and thus reduce the mobilization of vitamin A from the liver.
摘要
对26名新诊断的肺癌患者的血清维生素A浓度进行了测量，发现其显著低于年龄相仿的患有非恶性肺部疾病或非肺部疾病的患者。肺癌患者的维生素A水平与视黄醇结合蛋白（RBP）和锌的血清浓度显著相关，但对照组则不然。有人认为，低锌水平可能会减少RBP的合成，从而减少肝脏中维生素A的动员。
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