Zhu Yanlin, Hao Qingyu, Zhu Haixia, Zhao Ruoxi, Feng Lili, He Song, Wang Wenzhuo, He Guanting, Liu Bin, Yang Piaoping
Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China.
Infectious Disease Hospital of Heilongjiang Province, Harbin 150500, P. R. China.
ACS Nano. 2024 Dec 17;18(50):34257-34271. doi: 10.1021/acsnano.4c12261. Epub 2024 Dec 4.
Electron-hole recombination and exogenous local hypoxia both impede the effectiveness of thermoelectric tumor catalytic therapy. Here, a thermoelectric heterojunction (Pt-TiO/TiCT-PEG) was developed to enhance charge carrier separation and alleviate tumor hypoxia. By incorporating titanium oxide with oxygen vacancies and platinum single atoms onto TiCT MXene, we not only improve the charge separation efficiency but also prevent the recombination of positive and negative charges generated by the thermoelectric effect, leading to an increased production of reactive oxygen species (ROS). Furthermore, the Pt SAs exhibited excellent catalase-mimicking (CAT-mimicking) activity, catalyzing hydrogen peroxide to generate oxygen and alleviating the hypoxic tumor microenvironment. Titanium oxide with oxygen vacancies also serves as a sonosensitizer for sonodynamic therapy (SDT), enhancing ROS generation in collaboration with thermoelectric catalytic therapy. Moreover, the photothermal conversion efficiency of Pt-TiO/TiCT-PEG is augmented by Pt SAs with a surface plasmon resonance effect, further boosting CAT-mimicking activity and thermoelectric catalytic therapy efficacy. This tumor-specific thermoelectric heterojunction integrates thermoelectric therapy, SDT, and photothermal therapy, demonstrating excellent tumor suppression efficacy both in vitro and in vivo. Therefore, this study offers highly valuable and promising insights into utilizing photothermoelectric/ultrasound-mediated methods for cancer treatment.
电子-空穴复合和外源性局部缺氧均会阻碍热电肿瘤催化治疗的效果。在此，我们开发了一种热电异质结（Pt-TiO/TiCT-PEG）以增强电荷载流子分离并缓解肿瘤缺氧。通过将具有氧空位的氧化钛和铂单原子结合到TiCT MXene上，我们不仅提高了电荷分离效率，还防止了热电效应产生的正负电荷复合，从而增加了活性氧（ROS）的产生。此外，铂单原子表现出优异的过氧化氢酶模拟（CAT模拟）活性，催化过氧化氢产生氧气并缓解肿瘤缺氧微环境。具有氧空位的氧化钛还可作为声动力疗法（SDT）的声敏剂，与热电催化疗法协同增强ROS的产生。此外，具有表面等离子体共振效应的铂单原子提高了Pt-TiO/TiCT-PEG的光热转换效率，进一步增强了CAT模拟活性和热电催化治疗效果。这种肿瘤特异性热电异质结整合了热电疗法、SDT和声热疗法，在体外和体内均显示出优异的肿瘤抑制效果。因此，本研究为利用光热电/超声介导的方法治疗癌症提供了极具价值和前景的见解。
