Çelik Muhammed Emin, Soylu Veysel Garani, Yilmaz Ayse
Ankara Bilkent City Hospital, Intensive Care Unit - Ankara, Türkiye.
Kastamonu University, Faculty of Medicine, Intensive Care Unit - Kastamonu, Türkiye.
Arq Bras Cir Dig. 2024 Dec 2;37:e1837. doi: 10.1590/0102-6720202400043e1837. eCollection 2024.
Many free radicals result in an inflammatory process due to complications caused by gallstones. These free radicals are inactivated by various reactions and participate in different reactions. Molecules are oxidants and antioxidants that take an active role in almost every event that takes place in the body.
To analyse the changes in total antioxidant level (TAL) and total oxidant level (TOL) in the follow-up of patients hospitalized for cholelithiasis or its complications, showing the active oxidative stress, and to test the usability of these parameters in the evaluation of treatment success.
Forty-five patients took part in the study. Blood samples were taken twice, previous to surgery and 6 hours after surgery. Tissue samples were also obtained from patients who were operated. Then, the samples were sent to a laboratory to measure the total oxidant and antioxidant status of patients.
The median for the TAL_before (pre-operation or hospitalization in non-operational) variable was 2.40 (interquartile range - IQR=0.50), and the median for the TAL_after variable was 2.20 (IQR=0.33). The median of the tissue-derived TAL variable was 0.32 (IQR=0.13), and the median of the TOL variable was 0.43 (IQR=0.52). The median value of the TAL_before variable for men was 2.50 (IQR=0.50), while the median value for the TAL_before variable for women was 2.30 (IQR=0.50). TAL_before variable values did not show a statistically significant difference according to gender (Z=1.446; p=0.154, p>0.05). Similarly, the median values of TOL_before variable by gender were similar (Z=0.614; p=0.545, p>0.05).
Cholelithiasis and its complications cause many inflammatory responses, ending with free radical formation. During follow-up, its level decreases due to consumption or success of the treatment.
许多自由基会因胆结石引起的并发症导致炎症过程。这些自由基通过各种反应失活并参与不同反应。分子作为氧化剂和抗氧化剂，在身体发生的几乎每一个事件中都发挥着积极作用。
分析因胆石症或其并发症住院的患者在随访过程中总抗氧化水平（TAL）和总氧化剂水平（TOL）的变化，以显示活跃的氧化应激，并测试这些参数在评估治疗效果中的可用性。
45名患者参与了该研究。在手术前和手术后6小时采集血样。还从接受手术的患者身上获取组织样本。然后，将样本送去实验室测量患者的总氧化剂和抗氧化状态。
TAL_before（术前或非手术住院时）变量的中位数为2.40（四分位间距-IQR=0.50），TAL_after变量的中位数为2.20（IQR=0.33）。组织来源的TAL变量的中位数为0.32（IQR=0.13），TOL变量的中位数为0.43（IQR=0.52）。男性TAL_before变量的值中位数为2.50（IQR=0.50），而女性TAL_before变量的值中位数为2.30（IQR=0.50）。TAL_before变量值按性别未显示出统计学显著差异（Z=1.446；p=0.154，p>0.05）。同样，按性别划分的TOL_before变量中位数相似（Z=0.614；p=0.545，p>0.05）。
胆石症及其并发症会引起许多炎症反应，最终形成自由基。在随访期间，由于消耗或治疗成功，其水平会降低。
