Yu Huang, Liu Yankun, Zhang Tingyi, Guan Ziyi, Li Ping
Department of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Front Nutr. 2025 May 9;12:1557491. doi: 10.3389/fnut.2025.1557491. eCollection 2025.
Cardiovascular-kidney-metabolic (CKM) syndrome affects 25% of US adults, with chronic inflammation as a key pathophysiological mechanism. While the inflammatory basis of CKM syndrome is established, associations of the energy-adjusted dietary inflammatory index (E-DII) with CKM syndrome remain unexplored in the general population.
Using data from 7,110 participants in the National Health and Nutrition Examination Survey (2007-2018), we examined the association between E-DII (calculated from dietary recall data) and CKM syndrome (defined as co-occurrence of cardiometabolic syndrome and chronic kidney disease). Multiple logistic regression, restricted cubic spline analyses, weighted quantile sum regression, and quantile g-computation were performed to assess associations and dietary component contributions.
Higher E-DII scores correlated with increased CKM syndrome prevalence (OR: 1.22, 95% CI: 1.09-1.37). The relationship exhibited linearity ( for nonlinearity = 0.464). Stratified analyses across demographic and socioeconomic subgroups revealed consistent associations. Component analyses identified alcohol as the dietary factor with the strongest association with CKM syndrome.
The findings demonstrate a significant association between dietary inflammatory potential and CKM syndrome, with alcohol consumption emerging as a key modifiable factor. These results provide evidence-based insights for developing targeted dietary interventions in CKM syndrome prevention.
心血管-肾脏-代谢（CKM）综合征影响着25%的美国成年人，慢性炎症是其关键的病理生理机制。虽然CKM综合征的炎症基础已明确，但能量调整饮食炎症指数（E-DII）与CKM综合征在普通人群中的关联仍未得到探索。
利用美国国家健康与营养检查调查（2007 - 2018年）中7110名参与者的数据，我们研究了E-DII（根据饮食回忆数据计算得出）与CKM综合征（定义为心脏代谢综合征和慢性肾脏病同时出现）之间的关联。进行了多项逻辑回归、受限立方样条分析、加权分位数和回归以及分位数g计算，以评估关联和饮食成分的贡献。
较高的E-DII得分与CKM综合征患病率增加相关（比值比：1.22，95%置信区间：1.09 - 1.37）。这种关系呈线性（非线性检验P值 = 0.464）。在人口统计学和社会经济亚组中的分层分析显示出一致的关联。成分分析确定酒精是与CKM综合征关联最强的饮食因素。
研究结果表明饮食炎症潜能与CKM综合征之间存在显著关联，饮酒是一个关键的可改变因素。这些结果为制定针对CKM综合征预防的有针对性的饮食干预措施提供了基于证据的见解。
