Department of Clinical Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Clinical Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Front Immunol. 2023 Mar 15;14:1143980. doi: 10.3389/fimmu.2023.1143980. eCollection 2023.
The small nucleolar RNA host genes (SNHGs) are a group of genes that can be transcript into long non-coding RNA SNHG (lncSNHG) and further processed into small nucleolar RNAs (snoRNAs). Although lncSNHGs and snoRNAs are well established to play pivotal roles in tumorigenesis, how lncSNHGs and snoRNAs regulate the immune cell behavior and function to mediate anti-tumor immunity remains further illustrated. Certain immune cell types carry out distinct roles to participate in each step of tumorigenesis. It is particularly important to understand how lncSNHGs and snoRNAs regulate the immune cell function to manipulate anti-tumor immunity. Here, we discuss the expression, mechanism of action, and potential clinical relevance of lncSNHGs and snoRNAs in regulating different types of immune cells that are closely related to anti-tumor immunity. By uncovering the changes and roles of lncSNHGs and snoRNAs in different immune cells, we aim to provide a better understanding of how the transcripts of SNHGs participate in tumorigenesis from an immune perspective.
小核仁 RNA 宿主基因 (SNHGs) 是一组能够转录为长链非编码 RNA SNHG (lncSNHG) 并进一步加工成小核仁 RNA (snoRNAs) 的基因。尽管 lncSNHGs 和 snoRNAs 已被充分证实在肿瘤发生中发挥关键作用，但 lncSNHGs 和 snoRNAs 如何调节免疫细胞行为和功能以介导抗肿瘤免疫仍需进一步阐明。某些免疫细胞类型在肿瘤发生的每个步骤中发挥独特的作用。了解 lncSNHGs 和 snoRNAs 如何调节免疫细胞功能以操纵抗肿瘤免疫尤为重要。在这里，我们讨论了 lncSNHGs 和 snoRNAs 在调节与抗肿瘤免疫密切相关的不同类型免疫细胞中的表达、作用机制和潜在临床相关性。通过揭示不同免疫细胞中 lncSNHGs 和 snoRNAs 的变化和作用，我们旨在从免疫角度更好地理解 SNHGs 的转录物如何参与肿瘤发生。
