Joshi Beena Nitin, Chaurasia Himanshu, R Revathy, Shetty Siddesh, Kharat Namrata, Begum Shahina, Deshpande Aniruddha, Kangule Digambar, Acharya Shrikala, Deoraj Parmod, Sanap Pravin, Mashal Iranna
HTA Regional Resource Hub, Department of Operational and Implementation Research, ICMR- National Institute for Research in Reproductive and Child Health, Mumbai, Maharashtra, India.
Department of Biostatistics, ICMR- National Institute for Research in Reproductive and Child Health, Mumbai, Maharashtra, India.
PLoS One. 2024 Dec 5;19(12):e0314308. doi: 10.1371/journal.pone.0314308. eCollection 2024.
The incidence of unintended pregnancies and transmission of infection from mother-to-child could be averted by implementation of linked HIV care and family planning services (prong-2). The objective of the study was to assess the cost-effectiveness of strengthening prong-2 interventions through linked HIV-family planning services, to prevent unintended pregnancies among women living with HIV. A Markov decision analytical model was performed from a disaggregated societal perspective. A hypothetical cohort of married, sexually active women living with HIV in reproductive age, availing services from public health settings in India, were followed to estimate the costs and health outcomes. The intervention was strengthening linkage of HIV with family planning services through training healthcare providers and improving focus of dual methods of contraception. The standard of care with focus on condom promotion primarily for infection control was the comparator. The outcome was measured as Incremental Cost-effectiveness Ratio in terms of unintended pregnancies, live-births, abortions, maternal deaths and infant infections averted. We conducted Probabilistic Sensitivity Analysis to evaluate uncertainties. The intervention was found to be cost-effective. Among a cohort of 782107, 72604 unintended pregnancies, 41610 induced abortions, 17425 unintended live-births, and 8722 deaths were averted by the intervention. At 2% mother-to-child transmission rate, 2752 infant infections were averted. An incremental cost of INR 100000 (USD1272.3) could avert one death, two unintended live-births, five abortions and nine unintended pregnancies. Linking HIV and family planning services to prevent unintended pregnancy by use of dual contraception among women living with HIV is cost-effective.
通过实施艾滋病病毒关联护理与计划生育服务(第二 prong),可避免意外怀孕和母婴感染传播。本研究的目的是评估通过艾滋病病毒关联计划生育服务加强第二 prong 干预措施的成本效益,以预防感染艾滋病病毒的女性意外怀孕。从社会总体角度构建了马尔可夫决策分析模型。对印度公共卫生机构中假设的一组处于生育年龄、已婚、有性行为且感染艾滋病病毒的女性进行跟踪,以估计成本和健康结果。干预措施是通过培训医疗服务提供者并加强对双重避孕方法的关注,强化艾滋病病毒与计划生育服务的联系。以主要侧重于通过推广避孕套控制感染的标准护理作为对照。结果以避免意外怀孕、活产、堕胎、孕产妇死亡和婴儿感染方面的增量成本效益比来衡量。我们进行了概率敏感性分析以评估不确定性。结果发现该干预措施具有成本效益。在一组 782107 名女性中,该干预措施避免了 72604 次意外怀孕、41610 次人工流产、17425 次意外活产以及 8722 例死亡。在母婴传播率为 2%的情况下,避免了 2752 例婴儿感染。每增加 100000 印度卢比(1272.3 美元)的成本可避免 1 例死亡、2 次意外活产、5 次人工流产和 9 次意外怀孕。将艾滋病病毒与计划生育服务相联系,通过对感染艾滋病病毒的女性使用双重避孕方法预防意外怀孕具有成本效益。