Wu Zenghong, Xia Fangnan, Wang Weijun, Zhang Kun, Fan Mengke, Lin Rong
Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, State Key Laboratory of Biocatalysis and Enzyme Engineering, Biomedical Materials Engineering Research Center, Hubei University, Wuhan, China.
Eur J Heart Fail. 2025 Feb;27(2):354-365. doi: 10.1002/ejhf.3539. Epub 2024 Dec 5.
Understanding the global burden of disease attributable to high body mass index (BMI) is essential for informing public health strategies and interventions to mitigate the impact of obesity-related conditions.
The global deaths and disability-adjusted life years (DALYs) caused by high BMI were examined based on age, sex, year, and geographical location as well as socio-demographic index. Globally in 2021, the deaths and DALYs attributable to high BMI have risen 2.54-fold and 2.68-fold for both sexes when compared to 1990. The number of global deaths linked to high BMI has risen for females from 828 147.16 (95% uncertainty interval [UI] 407 103.20-1 302 480.38) in 1990 to 2 013 089.03 (95% UI 979 000.37-3 076 044.71) in 2021, and for males from 631 386.07 (95% UI 315 452.97-988 213.75) in 1990 to 1 695 974.32 (95% UI 861 972.49-2 635 343.31) in 2021. The number of DALYs related to high BMI worldwide has risen for females from 26 097 463.34 (95% UI 11 042 501.33-42 206 794.07) in 1990 to 67 213 785.86 (95% UI 28 417 735.35-105 552 568.89) in 2021, and for males from 21 944 645.99 (95% UI 10 106 039.21-35 110 379.12) in 1990 to 61 306 297.23 (95% UI 27 566 755.49-94 931 874.52) in 2021. However, the age-standardized rate of high-BMI-related deaths for females increased by 4.06% and 15.06% for males between 1990 and 2021, while the age-standardized rate of high-BMI-related DALYs increased by 21.60% for females and 31.22% for males. Across the 21 Global Burden of Disease regions, in 2021, the highest age-standardized rates of high-BMI-related deaths and DALYs were observed in Southern Sub-Saharan Africa (125.12, 95% UI 71.21-183.13) and Oceania (3712.97, 95% UI 1666.49-5765.84), respectively.
Efforts to promote healthy weight management, lifestyle modifications, and early intervention for obesity-related health complications are essential in reducing the morbidity and mortality associated with obesity and improving overall population health.
了解因高体重指数（BMI）导致的全球疾病负担，对于为公共卫生战略和干预措施提供信息以减轻肥胖相关疾病的影响至关重要。
基于年龄、性别、年份、地理位置以及社会人口指数，研究了高BMI导致的全球死亡人数和伤残调整生命年（DALYs）。2021年全球范围内，与1990年相比，高BMI导致的男女死亡人数和DALYs分别增长了2.54倍和2.68倍。与高BMI相关的全球女性死亡人数从1990年的828147.16（95%不确定区间[UI]407103.20 - 1302480.38）增至2021年的2013089.03（95%UI 979000.37 - 3076044.71），男性从1990年的631386.07（95%UI 315452.97 - 988213.75）增至2021年的1695974.32（95%UI 861972.49 - 2635343.31）。全球范围内与高BMI相关的女性DALYs从1990年的26097463.34（95%UI 11042501.33 - 42206794.07）增至2021年的67213785.86（95%UI 28417735.35 - 105552568.89），男性从1990年的21944645.99（95%UI 10106039.21 - 35110379.12）增至2021年的61306297.23（95%UI 27566755.49 - 94931874.52）。然而，1990年至2021年间，女性高BMI相关死亡的年龄标准化率增长了4.06%，男性增长了15.06%，而女性高BMI相关DALYs的年龄标准化率增长了21.60%，男性增长了31.22%。在21个全球疾病负担区域中，2021年，撒哈拉以南非洲南部（125.12，95%UI 71.21 - 183.13）和大洋洲（3712.97，95%UI 1666.49 - 5765.84）分别观察到与高BMI相关死亡和DALYs的最高年龄标准化率。
努力促进健康体重管理、改变生活方式以及对肥胖相关健康并发症进行早期干预，对于降低与肥胖相关的发病率和死亡率以及改善总体人群健康至关重要。
