Maigre Simon, Meurant Virginie
Emergency Department, Centre Hospitalier Universitaire Tivoli, La Louvière, BEL.
Cureus. 2024 Nov 4;16(11):e73019. doi: 10.7759/cureus.73019. eCollection 2024 Nov.
Minoxidil, commonly used as a topical agent for alopecia, is occasionally used for refractory hypertension due to its antihypertensive properties. We report a rare case of massive minoxidil intoxication leading to refractory vasoplegic shock in a 24-year-old male. The patient ingested 120 mL of 5% minoxidil solution, resulting in vasoplegic shock. Management included fluid resuscitation and norepinephrine support. The patient required norepinephrine for 180 hours to maintain mean arterial pressure, a duration unprecedented in the literature. This case underscores the potential for prolonged vasopressor dependency following massive minoxidil ingestion and highlights the necessity for intensive symptomatic management. This report adds to the limited literature on minoxidil intoxication and suggests that extensive supportive care can be prolonged.
米诺地尔通常作为治疗脱发的局部用药，因其具有降压特性，偶尔也用于治疗难治性高血压。我们报告了一例罕见的大量米诺地尔中毒病例，该病例导致一名24岁男性出现难治性血管麻痹性休克。患者摄入了120毫升5%的米诺地尔溶液，从而引发血管麻痹性休克。治疗措施包括液体复苏和去甲肾上腺素支持治疗。该患者需要使用去甲肾上腺素180小时以维持平均动脉压，这一持续时间在文献中尚无先例。该病例强调了大量摄入米诺地尔后出现长期血管升压药依赖的可能性，并突出了强化对症治疗的必要性。本报告补充了关于米诺地尔中毒的有限文献，并表明广泛的支持性治疗可能会延长。
