Houff Ashley N, Albers Sharon E, Kumar Monique
Dermatology, College of Medicine, University of Central Florida, Orlando, USA.
Dermatology, Morsani College of Medicine, University of South Florida, Tampa, USA.
Cureus. 2024 Nov 4;16(11):e73013. doi: 10.7759/cureus.73013. eCollection 2024 Nov.
Neuroblastoma is a malignant tumor derived from the neural crest cells that often involves the adrenal glands and rarely metastasizes to the skin. Here, we present a case of a nine-month-old male infant who presented with multiple noncompressible blue-purple subcutaneous nodules, initially suggestive of atypical deep hemangiomas. The ultrasound revealed a lack of increased vascularity of the masses and an adrenal mass, leading to a biopsy and diagnosis of a neuroblastoma involving the adrenal gland, liver, and skin. We demonstrate that metastatic neuroblastoma can mimic infantile hemangiomas and that noncompressible skin masses warrant further workup with ultrasonography to rule out neuroblastoma.
神经母细胞瘤是一种起源于神经嵴细胞的恶性肿瘤,常累及肾上腺,很少转移至皮肤。在此,我们报告一例9个月大男婴,其表现为多个不可压缩的蓝紫色皮下结节,最初提示为非典型深部血管瘤。超声检查显示肿块及肾上腺肿块无血管增多,遂进行活检,诊断为累及肾上腺、肝脏和皮肤的神经母细胞瘤。我们证明转移性神经母细胞瘤可模仿婴儿血管瘤,不可压缩的皮肤肿块需要进一步行超声检查以排除神经母细胞瘤。