Peñas M, Benito M
Biochem Biophys Res Commun. 1986 Mar 13;135(2):589-96. doi: 10.1016/0006-291x(86)90034-3.
The overt activity of hepatic carnitine palmitoyltransferase (CPT1) increased during the last day of gestation in the foetus and after prolonged starvation in the newborn kept at 37 degrees C. Its sensitivity to inhibition by malonyl-CoA decreased during the perinatal period studied. Brown fat CPT1 increased under the same experimental conditions. However, its sensitivity to malonyl-CoA remains unchanged. Hypothermia at 24 degrees C decreased in the liver and increased in brown adipose tissue CPT1 activity in response to fasting. Glucose injection at birth decreased CPT1 activity in the liver but did not have any effect in the presence of mannoheptulose. This effect of glucose was non-significant in brown adipose tissue.
在胎儿妊娠的最后一天以及在37摄氏度环境下长期饥饿的新生儿中，肝脏肉碱棕榈酰转移酶（CPT1）的明显活性增加。在所研究的围产期内，其对丙二酰辅酶A抑制作用的敏感性降低。在相同实验条件下，棕色脂肪CPT1增加。然而，其对丙二酰辅酶A的敏感性保持不变。24摄氏度的低温使肝脏中CPT1活性降低，而棕色脂肪组织中CPT1活性则因禁食而增加。出生时注射葡萄糖可降低肝脏中CPT1的活性，但在有甘露庚酮糖存在时则没有任何影响。葡萄糖的这种作用在棕色脂肪组织中不显著。
