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胎儿-新生儿过渡期肝脏肉碱棕榈酰转移酶活性的调节

Regulation of hepatic carnitine palmitoyltransferase activity during the foetal-neonatal transition.

作者信息

Saggerson E D, Carpenter C A

出版信息

FEBS Lett. 1982 Dec 13;150(1):177-80. doi: 10.1016/0014-5793(82)81329-x.

DOI:10.1016/0014-5793(82)81329-x
PMID:7160469
Abstract

Overt carnitine palmitoyl transferase (CPT1) activity was measured in liver mitochondria from foetal rats (21 days gestation) and from neonatal rats (1 day post-partum). Birth was accompanied by a 6-fold increase in CPT1 activity, a 14-fold decrease in sensitivity to inhibition by malonyl CoA and an increase in the nH and the S0.5 for palmitoyl CoA. The activity of latent enzyme (CPT2) was unaffected at birth.

摘要

测定了胎鼠（妊娠21天）和新生鼠（出生后1天）肝脏线粒体中肉碱棕榈酰转移酶（CPT1）的活性。出生时CPT1活性增加了6倍，对丙二酰辅酶A抑制的敏感性降低了14倍，棕榈酰辅酶A的nH和S0.5增加。潜在酶（CPT2）的活性在出生时未受影响。

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1
Regulation of hepatic carnitine palmitoyltransferase activity during the foetal-neonatal transition.胎儿-新生儿过渡期肝脏肉碱棕榈酰转移酶活性的调节
FEBS Lett. 1982 Dec 13;150(1):177-80. doi: 10.1016/0014-5793(82)81329-x.
2
The effect of malonyl-CoA on overt and latent carnitine acyltransferase activities in rat liver and adipocyte mitochondria.丙二酰辅酶A对大鼠肝脏和脂肪细胞线粒体中显性和潜在肉碱酰基转移酶活性的影响。
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3
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