尼日利亚和加纳饮酒与中风之间的关联：一项病例对照研究。
Association between alcohol consumption and stroke in Nigeria and Ghana: A case-control study.
作者信息
Chukwuonye Innocent Ijezie, Akpa Onoja Matthew, Asowata Osahon Jeffery, Fakunle Adekunle Gregory, Komolafe Morenikeji A, Akinyemi Joshua, Sarfo Fred Stephen, Akpalu Albert, Wahab Kolawole, Obiako Reginald, Owolabi Lukman, Osaigbovo Godwin O, Okekunle Akinkunmi Paul, Ogah Okechukwu, Tiwari Hemant K, Jekins Carolyn, Michael Fawale B, Arnett Donna, Calys-Tagoe Benedict, Olalere Abimbola, Adebayo Oladimeji, Oguike Wisdom, Adebayo Philip, Arulogun Oyedunni, Appiah Lambert, Ibinaiye Philip O, Adeniyi Sunday, Olalusi Oladotun, Balogun Olayemi, Akinyemi Rufus, Ovbiagele Bruce, Owolabi Mayowa Ojo
机构信息
Department of Medicine, Federal Medical Centre Umuahia, Umuahia, Nigeria.
Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria.
出版信息
Int J Stroke. 2025 Jun;20(5):590-600. doi: 10.1177/17474930241308458. Epub 2025 Jan 14.
BACKGROUND
The aim of the study was to examine the association between alcohol consumption and stroke in Nigeria and Ghana.
METHODS
The study is a multicentre, case-control study. Cases included consenting adults 18 years of age and older with acute stroke and controls were age-and -gender -matched stroke -free adults. Alcohol consumption was self-reported. The participants were classified into three alcohol-drinking status, which included abstainers, former drinkers, and current drinkers. The current drinkers were further classified into different alcohol drinking levels, including infrequent, light, moderate, heavy, and binge drinkers. Conditional logistic regression was used to determine associations between the drinking status and stroke, and the association between the different levels of current alcohol consumption and stroke. Five models were evaluated. Model 1 was unadjusted. Model 2 was adjusted for demographic characteristics. Model 3 included Model 2, lifestyle and psychosocial characteristics. Model 4 included Model 3 and dietary characteristics. Model 5 included Model 4 and metabolic characteristics.
RESULTS
A total of 7368 participants took part in the study. Half were stroke participants, and half were control participants. On the associations between drinking status and stroke, respectively, former drinkers showed no significant association with stroke. However, a significant association was observed between current drinkers and stroke in Models 1 and 2, with an odds ratio of 1.19 (95% CI: 1.04-1.38; p < 0.05) and 1.17 (95% CI: 1.01-1.36; p < 0.05), respectively. Regarding the various levels of current alcohol drinking and their association with stroke, no significant association was observed between light drinking and stroke in Model 5. In contrast, moderate drinkers, binge drinkers, and heavy drinkers showed a persistent and significant association with stroke respectively.
CONCLUSION
There is a significant association between stroke and current alcohol consumption, especially among heavy, binge, and moderate drinkers.
背景
本研究的目的是调查尼日利亚和加纳的酒精消费与中风之间的关联。
方法
本研究是一项多中心病例对照研究。病例包括18岁及以上同意参与研究的急性中风成年人，对照为年龄和性别匹配的无中风成年人。酒精消费情况通过自我报告获得。参与者被分为三种饮酒状态，包括戒酒者、既往饮酒者和当前饮酒者。当前饮酒者进一步分为不同的饮酒水平，包括偶尔饮酒者、轻度饮酒者、中度饮酒者、重度饮酒者和暴饮者。采用条件逻辑回归来确定饮酒状态与中风之间的关联，以及当前不同酒精消费水平与中风之间的关联。评估了五个模型。模型1未进行调整。模型2针对人口统计学特征进行了调整。模型3包括模型2、生活方式和社会心理特征。模型4包括模型3和饮食特征。模型5包括模型4和代谢特征。
结果
共有7368名参与者参与了本研究。一半是中风参与者，一半是对照参与者。关于饮酒状态与中风之间的关联，既往饮酒者与中风之间未显示出显著关联。然而，在模型1和模型2中，当前饮酒者与中风之间观察到显著关联，优势比分别为1.19（95%CI：1.04 - 1.38；p < 0.05）和1.17（95%CI：1.01 - 1.36；p < 0.05）。关于当前不同饮酒水平及其与中风的关联，在模型5中，轻度饮酒与中风之间未观察到显著关联。相比之下，中度饮酒者、暴饮者和重度饮酒者分别与中风显示出持续且显著的关联。
结论
中风与当前酒精消费之间存在显著关联，尤其是在重度、暴饮和中度饮酒者中。
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