• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

针对两种因酒精摄入量而培育的大鼠品系的昼夜饮酒节律和血液酒精水平。

Circadian drinking rhythms and blood alcohol levels in two rat lines developed for their alcohol consumption.

作者信息

Aalto J

出版信息

Alcohol. 1986 Jan-Feb;3(1):73-5. doi: 10.1016/0741-8329(86)90074-1.

DOI:10.1016/0741-8329(86)90074-1
PMID:3964440
Abstract

The circadian drinking behavior of the AA (Alko Alcohol) and ANA (Alko Non-Alcohol) rat lines developed for high and low voluntary alcohol consumption was studied by using a microcomputer lick-counting system. The blood alcohol concentrations of AA rats were measured during the drinking peaks. The results showed that AA rats voluntarily drink intoxicating amounts of alcohol. The highest blood alcohol levels were about 25 mmol/l. Differences in circadian drinking rhythms between AA and ANA lines were also found. AA rats had a trimodal drinking pattern for alcohol intake during the dark period but ANA rats drank alcohol rather evenly throughout the period.

摘要

利用微型计算机舔舐计数系统,对为高自愿酒精摄入量和低自愿酒精摄入量培育的AA(阿尔科酒精)和ANA(阿尔科非酒精)大鼠品系的昼夜饮酒行为进行了研究。在饮酒高峰期测量了AA大鼠的血液酒精浓度。结果表明,AA大鼠会自愿饮用致醉量的酒精。最高血液酒精水平约为25毫摩尔/升。还发现了AA和ANA品系之间昼夜饮酒节律的差异。AA大鼠在黑暗期的酒精摄入量呈三峰饮酒模式,而ANA大鼠在整个时期饮酒较为均匀。

相似文献

1
Circadian drinking rhythms and blood alcohol levels in two rat lines developed for their alcohol consumption.针对两种因酒精摄入量而培育的大鼠品系的昼夜饮酒节律和血液酒精水平。
Alcohol. 1986 Jan-Feb;3(1):73-5. doi: 10.1016/0741-8329(86)90074-1.
2
Effects of lifelong ethanol consumption on drinking behavior and motor impairment of alcohol-preferring AA and alcohol-avoiding ANA rats.终生摄入乙醇对嗜酒的AA大鼠和厌酒的ANA大鼠饮酒行为及运动功能损害的影响。
Alcohol. 2001 Apr;23(3):157-66. doi: 10.1016/s0741-8329(01)00132-x.
3
Associations of corticosterone and testosterone with alcohol drinking in F2 populations derived from AA and ANA rat lines.AA 和 ANA 大鼠品系的 F2 群体中皮质酮和睾酮与饮酒的关系。
Alcohol. 2011 Aug;45(5):421-6. doi: 10.1016/j.alcohol.2011.04.003. Epub 2011 May 28.
4
Determinants of alcohol preference in the AA and ANA rat lines selected for differential ethanol intake.为不同乙醇摄入量而选育的AA和ANA大鼠品系中酒精偏好的决定因素。
Alcohol Alcohol Suppl. 1991;1:115-20.
5
Repeated light-dark phase shifts modulate voluntary ethanol intake in male and female high alcohol-drinking (HAD1) rats.反复进行明暗周期转换可调节雄性和雌性高饮酒量(HAD1)大鼠的自愿乙醇摄入量。
Alcohol Clin Exp Res. 2007 Oct;31(10):1699-706. doi: 10.1111/j.1530-0277.2007.00476.x. Epub 2007 Aug 6.
6
GABA and glutamate overflow in the VTA and ventral pallidum of alcohol-preferring AA and alcohol-avoiding ANA rats after ethanol.酒精偏爱 AA 型和酒精回避 ANA 型大鼠在摄入乙醇后,VTA 和腹侧苍白球中 GABA 和谷氨酸的溢出。
Alcohol Alcohol. 2010 Mar-Apr;45(2):111-8. doi: 10.1093/alcalc/agp086. Epub 2010 Jan 13.
7
Pharmacologically relevant intake during chronic, free-choice drinking rhythms in selectively bred high alcohol-preferring mice.在选择性繁殖的高酒精偏好小鼠的慢性、自由选择饮酒节律中,药物相关的摄入。
Addict Biol. 2013 Nov;18(6):921-9. doi: 10.1111/j.1369-1600.2011.00412.x. Epub 2011 Nov 29.
8
The AA and ANA rat lines, selected for differences in voluntary alcohol consumption.AA和ANA大鼠品系,是根据自愿酒精摄入量的差异选择出来的。
Experientia. 1989 Sep 15;45(9):798-805. doi: 10.1007/BF01954055.
9
Voluntary alcohol drinking and acetaldehyde metabolism in F2 hybrid crosses of AA and ANA rat lines.AA和ANA大鼠品系F2杂交后代中的自愿饮酒与乙醛代谢
Pharmacol Biochem Behav. 1997 Mar;56(3):441-6. doi: 10.1016/s0091-3057(96)00136-0.
10
Differences between alcohol-preferring (AA) and alcohol-avoiding (ANA) rats in the prodynorphin and proenkephalin systems.嗜酒(AA)大鼠和厌酒(ANA)大鼠在前强啡肽和前脑啡肽系统中的差异。
Alcohol Clin Exp Res. 1994 Oct;18(5):1272-9. doi: 10.1111/j.1530-0277.1994.tb00118.x.

引用本文的文献

1
Rat animal models for screening medications to treat alcohol use disorders.用于筛选治疗酒精使用障碍药物的大鼠动物模型。
Neuropharmacology. 2017 Aug 1;122:201-243. doi: 10.1016/j.neuropharm.2017.02.004. Epub 2017 Feb 16.
2
Circadian activity rhythms and voluntary ethanol intake in male and female ethanol-preferring rats: effects of long-term ethanol access.雄性和雌性嗜酒大鼠的昼夜活动节律与自愿乙醇摄入量:长期接触乙醇的影响
Alcohol. 2014 Nov;48(7):647-55. doi: 10.1016/j.alcohol.2014.07.010. Epub 2014 Sep 16.
3
Effects of Lifelong Ethanol Consumption on Brain Monoamine Transmitters in Alcohol-Preferring Alko Alcohol (AA) Rats.
长期乙醇摄入对酒精偏爱型 Alko 酒精(AA)大鼠脑单胺递质的影响。
Brain Sci. 2013 May 15;3(2):790-9. doi: 10.3390/brainsci3020790.
4
Scheduled access alcohol drinking by alcohol-preferring (P) and high-alcohol-drinking (HAD) rats: modeling adolescent and adult binge-like drinking.酒精偏好(P)和高酒精摄入(HAD)大鼠的定时饮酒:建模青少年和成年期 binge-like 样饮酒。
Alcohol. 2014 May;48(3):225-34. doi: 10.1016/j.alcohol.2013.10.004. Epub 2013 Oct 31.
5
Early ethanol and water consumption: accumulating experience differentially regulates drinking pattern and bout parameters in male alcohol preferring (P) vs. Wistar and Sprague Dawley rats.早期乙醇和水的摄入:积累经验差异调节雄性酒精偏好(P)与 Wistar 和 Sprague Dawley 大鼠的饮酒模式和发作参数。
Physiol Behav. 2014 Jan 17;123:20-32. doi: 10.1016/j.physbeh.2013.09.015. Epub 2013 Oct 2.
6
Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.针对酒精滥用的药物开发的动物模型:神经生物学和药理学的有效性。
Pharmacol Biochem Behav. 2012 Nov;103(1):119-55. doi: 10.1016/j.pbb.2012.07.007. Epub 2012 Jul 25.
7
Chronic free-choice drinking in crossed high alcohol preferring mice leads to sustained blood ethanol levels and metabolic tolerance without evidence of liver damage.慢性自由选择饮酒的交叉高酒精偏好小鼠导致持续的血液乙醇水平和代谢耐受,没有肝损伤的证据。
Alcohol Clin Exp Res. 2013 Feb;37(2):194-201. doi: 10.1111/j.1530-0277.2012.01873.x. Epub 2012 Jul 3.
8
Pharmacologically relevant intake during chronic, free-choice drinking rhythms in selectively bred high alcohol-preferring mice.在选择性繁殖的高酒精偏好小鼠的慢性、自由选择饮酒节律中,药物相关的摄入。
Addict Biol. 2013 Nov;18(6):921-9. doi: 10.1111/j.1369-1600.2011.00412.x. Epub 2011 Nov 29.
9
Prairie voles as a novel model of socially facilitated excessive drinking.草原田鼠作为一种新型的社会促进过度饮酒模型。
Addict Biol. 2011 Jan;16(1):92-107. doi: 10.1111/j.1369-1600.2010.00234.x.
10
Chronic ethanol intake modulates photic and non-photic circadian phase responses in the Syrian hamster.长期摄入乙醇会调节叙利亚仓鼠的光周期和非光周期昼夜节律相位反应。
Pharmacol Biochem Behav. 2007 Aug-Sep;87(3):297-305. doi: 10.1016/j.pbb.2007.05.001. Epub 2007 May 10.