Li Kunjie, Chen Heng, Li Dayang, Yang Chaoyong, Zhang Huimin, Zhu Zhi
Key Laboratory of Spectrochemical Analysis and Instrumentation, Ministry of Education, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Department of Electronic Engineering, School of Electronic Science and Engineering, Xiamen University, Xiamen 361005, China.
ACS Appl Mater Interfaces. 2024 Dec 18;16(50):68749-68771. doi: 10.1021/acsami.4c13948. Epub 2024 Dec 8.
Information processing is a critical topic in the digital age, as silicon-based circuits face unprecedented challenges such as data explosion, immense energy consumption, and approaching physical limits. Deoxyribonucleic acid (DNA), naturally selected as a carrier for storing and using genetic information, possesses unique advantages for information processing, which has given rise to the emerging fields of DNA computing and DNA data storage. To meet the growing practical demands, a wide variety of materials and interfaces have been introduced into DNA information processing technologies, leading to significant advancements. This review summarizes the advances in materials and interfaces that facilitate DNA computation and DNA data storage. We begin with a brief overview of the fundamental functions and principles of DNA computation and DNA data storage. Subsequently, we delve into DNA computing systems based on various materials and interfaces, including microbeads, nanomaterials, DNA nanostructures, hydrophilic-hydrophobic compartmentalization, hydrogels, metal-organic frameworks, and microfluidics. We also explore DNA data storage systems, encompassing encapsulation materials, microfluidics techniques, DNA nanostructures, and living cells. Finally, we discuss the current bottlenecks and obstacles in the fields and provide insights into potential future developments.
在数字时代，信息处理是一个关键主题，因为基于硅的电路面临着前所未有的挑战，如数据爆炸、巨大的能量消耗以及接近物理极限。脱氧核糖核酸（DNA）作为存储和使用遗传信息的天然载体，在信息处理方面具有独特优势，这催生了DNA计算和DNA数据存储等新兴领域。为满足日益增长的实际需求，多种材料和界面已被引入DNA信息处理技术，带来了显著进展。本综述总结了促进DNA计算和DNA数据存储的材料和界面方面的进展。我们首先简要概述DNA计算和DNA数据存储的基本功能及原理。随后，我们深入探讨基于各种材料和界面的DNA计算系统，包括微珠、纳米材料、DNA纳米结构、亲水-疏水分隔、水凝胶、金属有机框架和微流控技术。我们还探索DNA数据存储系统，包括封装材料、微流控技术、DNA纳米结构和活细胞。最后，我们讨论该领域当前的瓶颈和障碍，并对潜在的未来发展提供见解。
