Andres T L, Trainer T D, Leadbetter G W
Urology. 1980 Mar;15(3):307-9. doi: 10.1016/0090-4295(80)90455-0.
This is the sixth reported case of metachronous testicular neoplasia in which a seminoma has preceded an embryonal carcinoma. Of particular note is the presence of atypical germ cells in the biopsy specimen of the gonad from which the embryonal carcinoma arose. There has developed recently an increasing awareness of germ cell atypia and carcinoma in situ. Pathologists examining testicular biopsies in the infertile patient should be alerted to this process.
这是第六例报告的异时性睾丸肿瘤病例，其中精原细胞瘤先于胚胎癌出现。特别值得注意的是，胚胎癌起源的性腺活检标本中存在非典型生殖细胞。最近，人们对生殖细胞异型性和原位癌的认识不断提高。检查不育患者睾丸活检的病理学家应警惕这一过程。
