Liu Danping, Guo Pei, Wang Yi, Li Weihong
Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Mol Neurosci. 2024 Nov 22;17:1516119. doi: 10.3389/fnmol.2024.1516119. eCollection 2024.
Neurogenesis has emerged as a promising therapeutic approach for central nervous system disorders. The role of neuronal mitochondria in neurogenesis is well-studied, however, recent evidence underscores the critical role of astrocytic mitochondrial function in regulating neurogenesis and the underlying mechanisms remain incompletely understood. This review highlights the regulatory effects of astrocyte mitochondria on neurogenesis, focusing on metabolic support, calcium homeostasis, and the secretion of neurotrophic factors. The effect of astrocytic mitochondrial dysfunction in the pathophysiology and treatment strategies of Alzheimer's disease and depression is discussed. Greater attention is needed to investigate the mitochondrial autophagy, dynamics, biogenesis, and energy metabolism in neurogenesis. Targeting astrocyte mitochondria presents a potential therapeutic strategy for enhancing neural regeneration.
神经发生已成为治疗中枢神经系统疾病的一种有前景的方法。神经元线粒体在神经发生中的作用已得到充分研究，然而，最近的证据强调了星形胶质细胞线粒体功能在调节神经发生中的关键作用，其潜在机制仍未完全明确。本综述重点介绍了星形胶质细胞线粒体对神经发生的调节作用，着重于代谢支持、钙稳态以及神经营养因子的分泌。同时讨论了星形胶质细胞线粒体功能障碍在阿尔茨海默病和抑郁症病理生理学及治疗策略中的影响。需要更多关注来研究神经发生过程中的线粒体自噬、动力学、生物发生及能量代谢。靶向星形胶质细胞线粒体是增强神经再生的一种潜在治疗策略。
