Smith E M, Burns T L
Cancer. 1985 Jan 15;55(2):432-7. doi: 10.1002/1097-0142(19850115)55:2<432::aid-cncr2820550223>3.0.co;2-9.
This study evaluates the effects of breast self-examination (BSE) on extent of disease in newly diagnosed Iowa Surveillance, Epidemiology, and End Results (SEER) breast cancer cases (population-based) between November 1980 and December 1981. Similar to previous findings, BSE patients are more likely to find their tumors than are non-BSE patients when performed two or more times each year. However, no significant improvement in tumor size, number of lymph nodes, or staging is found. In addition, comparison with age-frequency matched controls, although supporting various breast cancer risk factors, also seems to identify a BSE response bias since cases were significantly more likely to report performing BSE than controls (P less than 0.0001), and BSE cases versus non-BSE cases show no differences in risks of disease to suggest an association between potential awareness of disease risks with altered health behavior (performing BSE).
本研究评估了1980年11月至1981年12月期间，爱荷华州基于人群的新诊断监测、流行病学和最终结果（SEER）乳腺癌病例中，乳房自我检查（BSE）对疾病程度的影响。与之前的研究结果相似，每年进行两次或更多次BSE的患者比不进行BSE的患者更有可能发现自己的肿瘤。然而，在肿瘤大小、淋巴结数量或分期方面未发现显著改善。此外，与年龄频率匹配的对照组相比，尽管支持各种乳腺癌风险因素，但似乎也发现了BSE反应偏差，因为病例报告进行BSE的可能性明显高于对照组（P小于0.0001），并且BSE病例与非BSE病例在疾病风险方面没有差异，这表明疾病风险的潜在意识与改变的健康行为（进行BSE）之间没有关联。
