Mant D, Vessey M P, Neil A, McPherson K, Jones L
Br J Cancer. 1987 Feb;55(2):207-11. doi: 10.1038/bjc.1987.39.
The relationship between breast self examination (BSE) and breast cancer stage at diagnosis was examined in 616 women aged 15-59 years. Differences in tumour characteristics between those not practising BSE and those practising but not taught were small and inconstant. However, women who had both practised and had been taught BSE had more favourable tumours than the non-practising group. The difference was most marked in terms of tumour size and the involvement of axillary nodes. The proportions of women in the non-BSE and taught-BSE groups with each characteristic were respectively: size less than or equal to 2 cm 33% and 45%, T1 clinical stage 27% and 42%, and N0 pathological stage 37% and 50%. This advantage to taught-BSE women persisted after adjustment for the identified confounding factors of age, social class and oral contraceptive use. The likely impact on breast cancer mortality is difficult to assess, although the potential benefit of the lead time gained must not be ignored when assessing the costs and benefits of BSE.
对616名年龄在15至59岁之间的女性进行了乳腺自我检查（BSE）与诊断时乳腺癌分期之间关系的研究。未进行BSE的女性与进行了BSE但未接受指导的女性在肿瘤特征上的差异很小且不稳定。然而，既进行了BSE又接受过指导的女性所患肿瘤比未进行BSE的女性更有利。这种差异在肿瘤大小和腋窝淋巴结受累方面最为明显。未进行BSE组和接受过指导的BSE组具有每种特征的女性比例分别为：肿瘤大小小于或等于2厘米，分别为33%和45%；临床分期为T1，分别为27%和42%；病理分期为N0，分别为37%和50%。在对确定的年龄、社会阶层和口服避孕药使用等混杂因素进行调整后，接受过指导的BSE女性的这一优势依然存在。尽管在评估BSE的成本和效益时，获得的提前期的潜在益处不容忽视，但对乳腺癌死亡率的可能影响难以评估。
