Wafi Abdul, Khan Mohammad Mansoob
Research Center for Advanced Materials, National Research and Innovation Agency (BRIN), South Tangerang, Indonesia.
Department of Pharmacy, Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia.
Bioprocess Biosyst Eng. 2025 Apr;48(4):521-542. doi: 10.1007/s00449-024-03123-z. Epub 2024 Dec 31.
In recent years, zinc oxide nanoparticles (ZnO NPs) have gained much attention in biomedical applications because of their distinctive physicochemical features such as low toxicity and biocompatible properties. Traditional methods to produce ZnO NPs sometimes include harmful substances and considerable energy consumption, causing environmental issues and potential health risks. Nowadays, the concern of ZnO production has moved toward environmentally friendly and sustainable synthesis methods, using natural extracts or plant-based precursors. This review discusses the green synthesis of ZnO NPs utilizing various plant extracts for wound healing applications. Moreover, ZnO NPs have antibacterial characteristics, which can prevent infection, a substantial obstacle in wound healing. Their ability to maintain inflammation, proliferation, oxidative stress, and promote angiogenesis proves their critical role in wound closure. In addition, ZnO NPs can also be easily and ideally incorporated with wound dressings and scaffolds such as hydrogel, chitosan, cellulose, alginate, and other materials, due to their exceptional mechanical properties. The latest publication of green synthesis of ZnO NPs and their applications for wound healing has been discussed. Therefore, this review provides a current update of knowledge on the sustainable and biocompatible ZnO NPs for specific applications, i.e., wound healing applications. In addition, the green synthesis of ZnO NPs using plant extracts also provides a particular approach in terms of material preparation, which is different from previous review articles.
近年来，氧化锌纳米颗粒（ZnO NPs）因其独特的物理化学特性，如低毒性和生物相容性，在生物医学应用中备受关注。传统的制备ZnO NPs的方法有时会包含有害物质且能耗巨大，从而引发环境问题和潜在的健康风险。如今，ZnO的生产关注点已转向使用天然提取物或植物基前驱体的环境友好型和可持续合成方法。这篇综述讨论了利用各种植物提取物进行绿色合成ZnO NPs在伤口愈合应用方面的情况。此外，ZnO NPs具有抗菌特性，能够预防感染，而感染是伤口愈合过程中的一个重大障碍。它们维持炎症、增殖、氧化应激以及促进血管生成的能力证明了它们在伤口闭合中发挥的关键作用。另外，由于其优异的机械性能，ZnO NPs还能够轻松且理想地与伤口敷料和支架（如水凝胶、壳聚糖、纤维素、藻酸盐及其他材料）相结合。本文讨论了ZnO NPs绿色合成及其伤口愈合应用的最新研究成果。因此，这篇综述提供了关于可持续且生物相容的ZnO NPs在特定应用（即伤口愈合应用）方面的最新知识更新。此外，利用植物提取物绿色合成ZnO NPs在材料制备方面也提供了一种与以往综述文章不同的独特方法。
