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总体水和总脂肪量能否预测超重及肥胖患者的肾结石复发?

Can the Total Body Water and Total Fat Mass Predict Kidney Stone Recurrence in Overweight and Obese Patients?

作者信息

Pricop Catalin, Ivanuta Marius, Nikolic Mihaela, Ivanuta Ana-Maria, Botnariu Gina, Stan Andreea Elena, Puia Dragos

机构信息

Urology, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, ROU.

Urology, "Dr. C. I. Parhon" Clinical Hospital, Iasi, ROU.

出版信息

Cureus. 2024 Nov 10;16(11):e73367. doi: 10.7759/cureus.73367. eCollection 2024 Nov.

Abstract

Background Urolithiasis prophylaxis is a cornerstone for kidney stone formers. Obesity is a well-known risk factor for kidney stone recurrence. The objectives of this research were to highlight the correlations between the mean water intake and free water deficit (FWD) depending on plasma Na and weight. Methods Anthropometric and nutritional analysis was performed using a body analyzer with magnetic bioimpedance ankle-to-foot, which determined the total percentage of water in the body. Results The mean age was 52.19 years old and the mean body mass index (BMI) was 33.68 km/m. About 58.23% (n=46) of patients declared at least one episode of urolithiasis in their pathological antecedents. The patients were counseled by a dietician and lost weight. After losing weight, the total body water (TBW) percentage increased (average=41.37%), while the total fat percentage decreased (average=33.52%). Urinary volume increased, but the water did not accumulate for proper hydration. This may explain the recurrence of urinary stones despite large amounts of water intake. Conclusions The present study indicates an inverse-proportional relationship between TBW and fat mass (FM). Obese patients with lithiasis should lose weight due to total FM, not TBW.

摘要

背景

尿石症预防是肾结石患者的基石。肥胖是肾结石复发的一个众所周知的危险因素。本研究的目的是强调根据血浆钠和体重,平均水摄入量与自由水缺乏(FWD)之间的相关性。方法:使用具有磁生物阻抗踝至足的身体分析仪进行人体测量和营养分析,该分析仪可测定体内水的总百分比。结果:平均年龄为52.19岁,平均体重指数(BMI)为33.68kg/m²。约58.23%(n = 46)的患者在其病理既往史中宣称至少有一次尿石症发作。患者接受了营养师的咨询并减轻了体重。体重减轻后,全身水(TBW)百分比增加(平均 = 41.37%),而总脂肪百分比下降(平均 = 33.52%)。尿量增加,但水并未积聚以实现适当的水合作用。这可能解释了尽管摄入大量水,尿结石仍会复发的原因。结论:本研究表明TBW与脂肪量(FM)之间存在反比例关系。患有结石症的肥胖患者应因总FM而非TBW而减轻体重。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f1/11631159/2d439c3f2b1b/cureus-0016-00000073367-i01.jpg

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