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艾滋病中的脊髓退化

Spinal cord degeneration in AIDS.

作者信息

Goldstick L, Mandybur T I, Bode R

出版信息

Neurology. 1985 Jan;35(1):103-6. doi: 10.1212/wnl.35.1.103.

DOI:10.1212/wnl.35.1.103
PMID:3965981
Abstract

Ten months before his death, a 36-year-old homosexual man with AIDS developed progressive symmetric paraparesis with muscle wasting, paresthesias, reflex-uninhibited bladder function, and bowel incontinence. Neuropathologic postmortem examination revealed a symmetric degeneration of the lateral and anterior pyramidal tracts as well as the posterior columns. Scattered microglial nodules were present in the brain and spinal cord. The cause of this spinal cord complication remains uncertain. Possible etiologies of the demyelinating process include infectious, parainfectious, nutritional, paraneoplastic, and toxic causes.

摘要

在他去世前十个月,一名患有艾滋病的36岁同性恋男子出现进行性对称性截瘫,伴有肌肉萎缩、感觉异常、反射不受抑制的膀胱功能和大便失禁。死后神经病理学检查显示外侧和前锥体束以及后索对称性变性。脑和脊髓中存在散在的小胶质结节。这种脊髓并发症的病因仍不确定。脱髓鞘过程的可能病因包括感染性、感染后、营养性、副肿瘤性和中毒性原因。

相似文献

1
Spinal cord degeneration in AIDS.艾滋病中的脊髓退化
Neurology. 1985 Jan;35(1):103-6. doi: 10.1212/wnl.35.1.103.
2
Gracile tract degeneration in patients with sensory neuropathy and AIDS.感觉神经病变与艾滋病患者的薄束变性
Neurology. 1988 Feb;38(2):265-71. doi: 10.1212/wnl.38.2.265.
3
Vacuolar myelopathy pathologically resembling subacute combined degeneration in patients with the acquired immunodeficiency syndrome.空泡性脊髓病在获得性免疫缺陷综合征患者中,病理表现类似于亚急性联合变性。
N Engl J Med. 1985 Apr 4;312(14):874-9. doi: 10.1056/NEJM198504043121402.
4
Spinal cord syndromes in the acquired immune deficiency syndrome.获得性免疫缺陷综合征中的脊髓综合征
Acta Neurol Scand. 1986 Jun;73(6):590-8. doi: 10.1111/j.1600-0404.1986.tb04605.x.
5
[Neuropathologic changes in AIDS].[艾滋病的神经病理学变化]
Rev Med Interna Neurol Psihiatr Neurochir Dermatovenerol Neurol Psihiatr Neurochir. 1989 Jan-Mar;34(1):23-38.
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Vacuolar myelopathy in AIDS. A morphological analysis.
Pathol Res Pract. 1990 Apr;186(2):228-37. doi: 10.1016/S0344-0338(11)80540-6.
7
Ischaemic myelopathy secondary to disseminated intravascular coagulation in AIDS.
J Neurol. 1991 Feb;238(1):51-4. doi: 10.1007/BF00319713.
8
Neuropathology of the spinal cord in the acquired immunodeficiency syndrome.获得性免疫缺陷综合征的脊髓神经病理学
Hum Pathol. 1992 Oct;23(10):1106-14. doi: 10.1016/0046-8177(92)90028-2.
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[Vacuolar myelopathy: apropos of a new demyelinating complication in acquired immunodeficiency syndrome].[空泡性脊髓病:关于获得性免疫缺陷综合征中的一种新的脱髓鞘并发症]
Med Clin (Barc). 1987 Mar 7;88(9):375-7.
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[Spinal cord involvement by the human immunodeficiency virus. Vacuolar myelopathy].[人类免疫缺陷病毒所致脊髓受累。空泡性脊髓病]
Arch Neurobiol (Madr). 1989;52 Suppl 1:73-8.

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Neuroradiology. 2011 Aug;53(8):585-92. doi: 10.1007/s00234-010-0782-6. Epub 2010 Nov 3.
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Neuropathologic contributions to understanding AIDS and the central nervous system.神经病理学对理解艾滋病和中枢神经系统的贡献。
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MR findings in AIDS-associated myelopathy.艾滋病相关性脊髓病的磁共振成像表现
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4
Spinal tract pathology in AIDS: postmortem MRI correlation with neuropathology.
Neuroradiology. 1995 Feb;37(2):134-8. doi: 10.1007/BF00588630.
5
Cerebral toxoplasmosis in AIDS. Case report.艾滋病相关的脑弓形虫病。病例报告。
Ital J Neurol Sci. 1988 Apr;9(2):161-3. doi: 10.1007/BF02337464.
6
Neurologic complications of the acquired immune deficiency syndrome.获得性免疫缺陷综合征的神经系统并发症
J Natl Med Assoc. 1987 Aug;79(8):833-40.
7
Neurological complications in AIDS.艾滋病的神经并发症
J Neurol. 1987 Jun;234(5):269-79. doi: 10.1007/BF00314279.
8
Neurological complications of human immunodeficiency virus infection.人类免疫缺陷病毒感染的神经系统并发症
Postgrad Med J. 1988 Mar;64(749):180-7. doi: 10.1136/pgmj.64.749.180.
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Dementia and ataxia in a patient with AIDS.一名艾滋病患者出现痴呆和共济失调。
West J Med. 1987 Jan;146(1):68-72.
10
The neuropathology of AIDS. UCLA experience and review.艾滋病的神经病理学。加州大学洛杉矶分校的经验与综述。
Am J Pathol. 1986 Sep;124(3):537-58.