人类免疫缺陷病毒感染的神经系统并发症
Neurological complications of human immunodeficiency virus infection.
作者信息
Kennedy P G
机构信息
Glasgow University Department of Neurology, Southern General Hospital, UK.
出版信息
Postgrad Med J. 1988 Mar;64(749):180-7. doi: 10.1136/pgmj.64.749.180.
Abstract
The protean neurological manifestations of human immunodeficiency virus (HIV) infection are reviewed. Both the central nervous system and peripheral nervous system may be affected and many of the complications may occur in individuals with acquired immunodeficiency syndrome (AIDS)-related complex, or who are seropositive for HIV alone as well as those with the established AIDS syndrome. Specific therapy is available for certain of these neurological conditions, but the clinical course in others is untreatable and progressive. Although it seems likely that the pathogenesis of some of these syndromes such as the AIDS-dementia complex are due to the direct effect of HIV on the nervous system, in others the neurological injury probably occurs as a consequence of the immunosuppression which HIV induces, or immune-mediated mechanisms.
摘要
本文综述了人类免疫缺陷病毒（HIV）感染的多种神经学表现。中枢神经系统和周围神经系统均可受累，许多并发症可发生于患有获得性免疫缺陷综合征（AIDS）相关综合征的个体、仅HIV血清学阳性的个体以及已确诊AIDS综合征的个体。其中某些神经疾病有特效疗法，但其他疾病的临床病程无法治疗且呈进行性发展。尽管某些综合征（如AIDS痴呆综合征）的发病机制似乎是HIV对神经系统的直接作用，但其他情况下，神经损伤可能是HIV诱导的免疫抑制或免疫介导机制所致。
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