Le Minh Tam, Nguyen Thai Thanh Thi, Nguyen Trung Van, Nguyen Quoc Huy Vu
Center for Reproductive Endocrinology and Infertility, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
Department of Obstetrics and Gynaecology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
Clin Exp Reprod Med. 2025 Sep;52(3):236-243. doi: 10.5653/cerm.2024.07136. Epub 2024 Dec 11.
Follicular fluid (FF) oxidation-reduction potential (ORP) has shown promise as a predictor for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes has been demonstrated. This study aimed to determine the association between the ORP in FF and IVF/ICSI outcomes.
This cross-sectional study involved data collection from 341 couples undergoing IVF/ICSI treatment. The FF sample was taken from the first follicle to exceed 18 mm during oocyte retrieval and was analyzed for ORP using the MiOXSYS system (Caerus Biotechnologies).
ORP in FF exhibited a statistically significant negative correlation with the fertilization rate (correlation coefficient, -0.126; p=0.019). The ORP levels in the FF from the group with a lower fertilization rate (<80%) were significantly higher than those in the group with a higher fertilization rate (≥80%) (89.90 mV vs. 78.98 mV, p=0.030). No significant correlations were found between ORP in FF and other outcomes.
Our findings suggested that the ORP in FF may be correlated with the fertilization rate and could be evaluated as a predictor of fertilization in ICSI.
卵泡液（FF）的氧化还原电位（ORP）已显示出有望作为体外受精/卵胞浆内单精子注射（IVF/ICSI）结局的预测指标。本研究旨在确定FF中的ORP与IVF/ICSI结局之间的关联。
这项横断面研究收集了341对接受IVF/ICSI治疗的夫妇的数据。在取卵过程中，从第一个直径超过18 mm的卵泡中采集FF样本，并使用MiOXSYS系统（Caerus生物技术公司）分析其ORP。
FF中的ORP与受精率呈统计学显著负相关（相关系数，-0.126；p=0.019）。受精率较低（<80%）组的FF中ORP水平显著高于受精率较高（≥80%）组（89.90 mV对78.98 mV，p=0.030）。未发现FF中的ORP与其他结局之间存在显著相关性。
我们的研究结果表明，FF中的ORP可能与受精率相关，可作为ICSI受精的预测指标进行评估。
