Xing Hui, McGregor Sarah K M, Batista Bruna D, Whitefield Cassidy, Stone Isobella S J, Murray Cody-Ellen, Hurst Rebecca M, Liu Yizhou, Chow Sharon, Fahrenhorst-Jones Tyler, Zhao Qi, Houston Sevan D, Hu Shu-Hong, Lonhienne Thierry, Nouwens Amanda, Burns Jed M, Savage G Paul, Walter Gimme H, Guddat Luke W, Rafter Michelle A, Williams Craig M
School of Chemistry and Molecular Biosciences, University of Queensland Brisbane 4072 Queensland Australia
Health and Biosecurity, CSIRO, Ecosciences Precinct Brisbane 4102 Queensland Australia.
Chem Sci. 2024 Dec 10;16(2):649-658. doi: 10.1039/d4sc06923d. eCollection 2025 Jan 2.
Weed management is an essential intervention for maintaining food security and protecting biodiversity but is heavily reliant on chemical control measures (, herbicides). Concerningly, only one herbicide has been developed with a new mode of action (MOA) since the 1980s. Therefore, alternative strategies for preventing weed growth need to be explored. The lesser-known concept of halting weed growth through herbistasis could be one strategy to alleviate the lack of success in obtaining new MOA leads, but this type of activity has rarely been investigated. Herein reported is a bioisosteric cyclooctatetraene (COT) for phenyl ring replacement tactic, using the commercial acetolactate synthase (ALS) inhibitor metsulfuron methyl, that has unearthed a rare agent displaying herbistatic properties against the weed, (rubber vine).
杂草管理是维护粮食安全和保护生物多样性的一项重要干预措施，但严重依赖化学控制措施（即除草剂）。令人担忧的是，自20世纪80年代以来，仅开发出一种具有新作用模式（MOA）的除草剂。因此，需要探索防止杂草生长的替代策略。通过植物生长停滞来阻止杂草生长这一鲜为人知的概念可能是一种策略，以缓解在获取新的作用模式线索方面缺乏成效的问题，但这类活性很少被研究。本文报道了一种用于苯环替代策略的生物电子等排体环辛四烯（COT），使用商业乙酰乳酸合酶（ALS）抑制剂甲磺隆，它发现了一种罕见的对杂草（橡胶藤）具有植物生长停滞特性的药剂。
