Yang Yilin, Hu Xiaoping, Liu Yuxin, Ouyang Bin, Zhang Jiaxi, Jin Huawei, Yu Zhenhua, Liu Ruiwei, Li Zhe, Jiang Lelun, Lin Xudong, Xu Bingzhe
Department of Biomedical Engineering, Sun Yat-sen University, Shenzhen Campus, No. 66, Gongchang Road, Guangming District, Shenzhen, Guangdong 518107, P.R. China.
The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Rd., Yuexiu District, Guangzhou, Guangdong 510080, P.R. China.
Sci Adv. 2022 Jul 22;8(29):eabm5023. doi: 10.1126/sciadv.abm5023.
Brain tumors have been proved challenging to treat. Here, we present a promising alternative by developing an implantable ultrasound-powered tumor treating device (UP-TTD) that electromagnetically disrupts the rapid division of cancer cells without any adverse effects on normal neurons, thereby safely inhibiting brain cancer recurrence. In vitro and in vivo experiments confirmed the significant therapeutic effect of the UP-TTD, with ~58% inhibition on growth rate of clinical tumor cells and ~78% reduction of cancer area in tumor-bearing rats. This UP-TTD is wireless ultrasound-powered, chip-sized, lightweight, and easy to operate on complex surfaces, with a largely boosting therapeutic efficiency and reducing energy consumption. Meanwhile, various treatment parameters could be tuned from the UP-TTD without increasing its size or adding circuits on the integrated chip. The tuning process was simulated and discussed, showing an excellent agreement with the experimental data. The encouraging results of the UP-TTD raise the possibility of a new modality for brain cancer treatment.
事实证明，脑肿瘤的治疗颇具挑战性。在此，我们通过研发一种可植入的超声驱动肿瘤治疗设备（UP-TTD），提出了一种很有前景的替代方案。该设备通过电磁干扰癌细胞的快速分裂，同时对正常神经元没有任何不良影响，从而安全地抑制脑癌复发。体外和体内实验证实了UP-TTD具有显著的治疗效果，对临床肿瘤细胞的生长速率抑制约58%，对荷瘤大鼠的癌灶面积缩小约78%。这种UP-TTD由无线超声供电，芯片尺寸，重量轻，易于在复杂表面操作，在很大程度上提高了治疗效率并降低了能耗。同时，无需增加其尺寸或在集成芯片上添加电路，就可以从UP-TTD调整各种治疗参数。对调整过程进行了模拟和讨论，结果与实验数据高度吻合。UP-TTD令人鼓舞的结果增加了脑癌治疗新方式的可能性。
