Pan Hsueh-Yi, Wu Li-Wei, Wang Pin-Chun, Chiu Ping-Hung, Wang Meng-Ting
Department of Pharmacy, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, ROC.
J Food Drug Anal. 2022 Sep 15;30(3):316-330. doi: 10.38212/2224-6614.3428.
Herbal medicine (HM) is a type of medicine that uses active ingredients made from plants to treat diseases and maintain health and wellbeing. Due to its increasing worldwide usage, the possibility of HMs and conventional drugs being concurrently used is high, potentially leading to adverse events resulting from herb-drug interactions. Despite the safety concerns regarding such interactions, few studies have been conducted for assessing clinical consequences of using HMs with conventional drugs in real-world settings. As clinical trials are not forthcoming rapidly enough to provide the evidence for herb-drug interactions, observational studies are considered as an alternative approach. The present review focuses on evaluating the utility of analyzing real-world data in observational research to study the clinical consequences of herb-drug interactions between HMs and conventional drugs. The data sources and study designs of each highlighted literature are examined based on its strengths and limitations in analyzing herb-drug interactions. Finally, future observational studies involving novel and rigorous methodologies that may be effective in studying herb-drug interactions are discussed.
草药医学（HM）是一种使用植物制成的活性成分来治疗疾病以及维持健康和福祉的医学类型。由于其在全球范围内的使用日益增加，草药与传统药物同时使用的可能性很高，这可能会导致草药 - 药物相互作用引发不良事件。尽管存在关于此类相互作用的安全担忧，但在现实环境中评估草药与传统药物联合使用的临床后果的研究却很少。由于临床试验的进展不够迅速，无法提供草药 - 药物相互作用的证据，因此观察性研究被视为一种替代方法。本综述着重评估在观察性研究中分析真实世界数据以研究草药与传统药物之间草药 - 药物相互作用的临床后果的效用。根据每篇重点文献在分析草药 - 药物相互作用方面的优势和局限性，对其数据来源和研究设计进行了审视。最后，讨论了未来可能有效研究草药 - 药物相互作用的新颖且严谨的观察性研究方法。
