scTrends：商业单细胞和空间组学技术的实时综述。
scTrends: A living review of commercial single-cell and spatial 'omic technologies.
作者信息
De Jonghe Joachim, Opzoomer James W, Vilas-Zornoza Amaia, Nilges Benedikt S, Crane Peter, Vicari Marco, Lee Hower, Lara-Astiaso David, Gross Torsten, Morf Jörg, Schneider Kim, Cudini Juliana, Ramos-Mucci Lorenzo, Mooijman Dylan, Tiklová Katarína, Salas Sergio Marco, Langseth Christoffer Mattsson, Kashikar Nachiket D, Schapiro Denis, Lundeberg Joakim, Nilsson Mats, Shalek Alex K, Cribbs Adam P, Taylor-King Jake P
机构信息
Francis Crick Institute, London, UK.
Cell Communication Lab, Department of Oncology, University College London Cancer Institute, London, UK; Relation Therapeutics, London, UK.
出版信息
Cell Genom. 2024 Dec 11;4(12):100723. doi: 10.1016/j.xgen.2024.100723.
Understanding the rapidly evolving landscape of single-cell and spatial omic technologies is crucial for advancing biomedical research and drug development. We provide a living review of both mature and emerging commercial platforms, highlighting key methodologies and trends shaping the field. This review spans from foundational single-cell technologies such as microfluidics and plate-based methods to newer approaches like combinatorial indexing; on the spatial side, we consider next-generation sequencing and imaging-based spatial transcriptomics. Finally, we highlight emerging methodologies that may fundamentally expand the scope for data generation within pharmaceutical research, creating opportunities to discover and validate novel drug mechanisms. Overall, this review serves as a critical resource for navigating the commercialization and application of single-cell and spatial omic technologies in pharmaceutical and academic research.
了解单细胞和空间组学技术快速发展的格局对于推动生物医学研究和药物开发至关重要。我们对成熟和新兴的商业平台进行了实时综述，突出了塑造该领域的关键方法和趋势。这篇综述涵盖了从微流控和基于平板的方法等基础单细胞技术到组合索引等新方法；在空间方面，我们考虑了下一代测序和基于成像的空间转录组学。最后，我们强调了可能从根本上扩大药物研究中数据生成范围的新兴方法，为发现和验证新的药物作用机制创造机会。总体而言，这篇综述是指导单细胞和空间组学技术在制药和学术研究中的商业化和应用的重要资源。
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