Li Maggie, Hunt Bijou, Balani Bindu, Ogedegbe Chinwe, Gordon Peter, Hayden Joshua, Glick Nancy, Chang Anita, Wang Su, Caponi Mitchell, Yarber-Cambron Lisa, Bhat Sandeep, Ward Tyshea, Suryadevara Madhu
Sinai Infectious Disease Center, Sinai Chicago, Chicago, Illinois, USA.
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
J Viral Hepat. 2025 Jan;32(1):e14043. doi: 10.1111/jvh.14043.
Hepatitis D (HDV) is a severe infection with well-recognised clinical ramifications that remains relatively neglected and underdiagnosed; consequently, the epidemiology of HDV is poorly characterised, both in the United States and globally. In 2022, a pilot project involving eight healthcare institutions was undertaken to ascertain the prevalence of HDV in healthcare institutions with an HBV seropositivity of at least 1%, describe the characteristics of patients testing positive for HDV, and evaluate diagnostic and laboratory processes of HDV screening. From August 2022 to April 2024, a total of 106,693 patients were tested for HBsAg, of whom 65,341 (61.2%) were female and 40,863 (38.3%) were male, with a mean age of 47 years. The overall HBsAg positivity rate was 1.04% (n = 1112). Among the HBsAg+ samples, 645 (58.0%) underwent HDV Ab testing. The HDV Ab positivity rate was 0.81% (n = 9), with 2 cases of HDV RNA positivity (0.18%). The incomplete testing reflects several challenges associated with screening for both HBV and HDV. Further research is necessary to better understand the epidemiology and burden of HDV in the United States and considerations for implementation.
丁型肝炎（HDV）是一种严重感染，具有公认的临床后果，但仍相对被忽视且诊断不足；因此，在美国和全球范围内，HDV的流行病学特征都不明确。2022年，开展了一个涉及八家医疗机构的试点项目，以确定HBV血清阳性率至少为1%的医疗机构中HDV的流行情况，描述HDV检测呈阳性患者的特征，并评估HDV筛查的诊断和实验室流程。从2022年8月到2024年4月，共有106,693名患者接受了HBsAg检测，其中65,341名（61.2%）为女性，40,863名（38.3%）为男性，平均年龄为47岁。总体HBsAg阳性率为1.04%（n = 1112）。在HBsAg阳性样本中，645份（58.0%）进行了HDV抗体检测。HDV抗体阳性率为0.81%（n = 9），HDV RNA阳性2例（0.18%）。检测不完整反映了与HBV和HDV筛查相关的几个挑战。有必要进行进一步研究，以更好地了解美国HDV的流行病学和负担以及实施方面的考虑因素。
