慢性阻塞性肺疾病患者膳食镁摄入量与衰弱之间的关联：美国国家健康与营养检查调查
The Association Between Dietary Magnesium Intake and Frailty in Patients with Chronic Obstructive Pulmonary Disease: National Health and Nutrition Examination Survey.
作者信息
Liang Minghao, Ren Xiuhong, Zhang Qiuxiang, Ruan Zhishen, Jin Minyan, Xu Yifei, Chen Xianhai, Qiu Zhanjun
机构信息
First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China.
Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
出版信息
Int J Chron Obstruct Pulmon Dis. 2024 Dec 7;19:2651-2660. doi: 10.2147/COPD.S485017. eCollection 2024.
BACKGROUND
Patients with chronic obstructive pulmonary disease (COPD) are at high risk of developing frailty and need to be prevented and managed. This study aims to investigate the relationship between dietary magnesium (Mg) intake and the risk of frailty in patients with COPD.
METHODS
We conducted a cross-sectional study from the National Health and Nutrition Examination Survey (NHANES) in the United States, focusing on patients with COPD. We used logistic regression to determine the adjusted odds ratios (OR) and 95% confidence interval (CI). Curve fitting, subgroup analysis, and sensitivity analysis were performed to further assess the relationship between dietary Mg intake and frailty in patients with COPD.
RESULTS
There were 1696 participants in this study, and the mean age was 60.4 ± 0.4 years. Weighted logistic regression and curve fitting showed a linear relationship between dietary Mg intake and frailty in patients with COPD. The risk of frailty decreased by 15% for each 100-unit increase in Mg intake (OR: 0.85, 95% CI: 0.76-0.96). Participants in the highest quartile Q4 of Mg intake had a lower risk of frailty than those in the lowest quartile Q1 (OR: 0.48, 95% CI: 0.32-0.72).
CONCLUSION
There is a linear relationship between dietary Mg intake and frailty in patients with COPD. Increasing dietary Mg intake is associated with a decreased risk of frailty in COPD.
背景
慢性阻塞性肺疾病（COPD）患者发生衰弱的风险很高，需要进行预防和管理。本研究旨在调查饮食中镁（Mg）摄入量与COPD患者衰弱风险之间的关系。
方法
我们对美国国家健康与营养检查调查（NHANES）进行了一项横断面研究，重点关注COPD患者。我们使用逻辑回归来确定调整后的优势比（OR）和95%置信区间（CI）。进行曲线拟合、亚组分析和敏感性分析，以进一步评估饮食中Mg摄入量与COPD患者衰弱之间的关系。
结果
本研究共有1696名参与者，平均年龄为60.4±0.4岁。加权逻辑回归和曲线拟合显示，饮食中Mg摄入量与COPD患者的衰弱之间存在线性关系。Mg摄入量每增加100单位，衰弱风险降低15%（OR：0.85，95%CI：0.76-0.96）。Mg摄入量最高四分位数Q4的参与者比最低四分位数Q1的参与者衰弱风险更低（OR：0.48，95%CI：0.32-0.72）。
结论
COPD患者饮食中Mg摄入量与衰弱之间存在线性关系。增加饮食中Mg摄入量与降低COPD患者的衰弱风险相关。
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