美国猪源分离株的抗菌药物耐药性与遗传多样性的比较分析
Comparative analysis of antimicrobial resistance and genetic diversity of isolates obtained from swine within the United States.
作者信息
Nicholson Tracy L, Shore Sarah M
机构信息
National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, United States.
出版信息
Front Microbiol. 2024 Nov 28;15:1501373. doi: 10.3389/fmicb.2024.1501373. eCollection 2024.
INTRODUCTION
is bacterial pathogen that is pervasive in swine populations and serves multiple roles in respiratory disease.
METHODS
This study utilized whole-genome sequencing (WGS) analysis to assess the sequence type (ST), identify the genetic diversity of genes predicted to encode regulatory and virulence factors, and evaluated any potential antimicrobial resistance harbored by isolates obtained from swine within the U.S.
RESULTS
While a generally high degree of genomic conservation was observed among the swine isolates, genetic diversity was identified within the locus and among the sequence type six (ST6) isolates. The majority of isolates exhibited phenotypic resistance to four antibiotic classes, however, only three antimicrobial resistance genes were identified.
DISCUSSION
Combined the data suggests that isolates are not serving as a source of antimicrobial resistance gene transference in the swine production environment.
引言
是一种在猪群中普遍存在的细菌病原体，在呼吸道疾病中发挥多种作用。
方法
本研究利用全基因组测序（WGS）分析来评估序列类型（ST），鉴定预测编码调节因子和毒力因子的基因的遗传多样性，并评估从美国猪中分离出的菌株所具有的任何潜在抗菌抗性。
结果
虽然在猪分离株中观察到普遍高度的基因组保守性，但在该位点内和序列类型六（ST6）分离株之间发现了遗传多样性。大多数分离株对四类抗生素表现出表型抗性，然而，仅鉴定出三个抗菌抗性基因。
讨论
综合数据表明，猪分离株在猪生产环境中不是抗菌抗性基因转移的来源。
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