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BvgR、RisA和RisS对……中全局基因调控、细胞内环二鸟苷水平、运动性和生物膜形成的贡献。

The contribution of BvgR, RisA, and RisS to global gene regulation, intracellular cyclic-di-GMP levels, motility, and biofilm formation in .

作者信息

Nicholson Tracy L, Waack Ursula, Fleming Damarius S, Chen Qing, Miller Laura C, Merkel Tod J, Stibitz Scott

机构信息

Agricultural Research Service, USDA, National Animal Disease Center, Ames, IA, United States.

United States Department of Energy, Oak Ridge Institute for Science and Education, Oak Ridge, TN, United States.

出版信息

Front Microbiol. 2024 Mar 7;15:1305097. doi: 10.3389/fmicb.2024.1305097. eCollection 2024.

DOI:10.3389/fmicb.2024.1305097
PMID:38516008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10955343/
Abstract

is a highly contagious respiratory bacterial veterinary pathogen. In this study the contribution of the transcriptional regulators BvgR, RisA, RisS, and the phosphorylation of RisA to global gene regulation, intracellular cyclic-di-GMP levels, motility, and biofilm formation were evaluated. Next Generation Sequencing (RNASeq) was used to differentiate the global gene regulation of both virulence-activated and virulence-repressed genes by each of these factors. The BvgAS system, along with BvgR, RisA, and the phosphorylation of RisA served in cyclic-di-GMP degradation. BvgR and unphosphorylated RisA were found to temporally regulate motility. Additionally, BvgR, RisA, and RisS were found to be required for biofilm formation.

摘要

是一种具有高度传染性的呼吸道细菌性兽医病原体。在本研究中，评估了转录调节因子BvgR、RisA、RisS以及RisA的磷酸化对全局基因调控、细胞内环二鸟苷酸水平、运动性和生物膜形成的作用。使用下一代测序（RNA测序）来区分这些因素对毒力激活基因和毒力抑制基因的全局基因调控。BvgAS系统以及BvgR、RisA和RisA的磷酸化参与环二鸟苷酸的降解。发现BvgR和未磷酸化的RisA可暂时调节运动性。此外，发现生物膜形成需要BvgR、RisA和RisS。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/831c037df01c/fmicb-15-1305097-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/50a1445a1ac9/fmicb-15-1305097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/0ef9632f7dac/fmicb-15-1305097-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/5d8fac1970f3/fmicb-15-1305097-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/e16305dd3ee8/fmicb-15-1305097-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/314972d10ca8/fmicb-15-1305097-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/831c037df01c/fmicb-15-1305097-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/50a1445a1ac9/fmicb-15-1305097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/0ef9632f7dac/fmicb-15-1305097-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/5d8fac1970f3/fmicb-15-1305097-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/e16305dd3ee8/fmicb-15-1305097-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/314972d10ca8/fmicb-15-1305097-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06a3/10955343/831c037df01c/fmicb-15-1305097-g006.jpg

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