Pillai Jayachithra Ramakrishna, Wali Adil Farooq, Shivappa Pooja, Talath Sirajunisa, Attia Sabry M, Nadeem Ahmed, Rehman Muneeb U
Department of Pharmaceutical Chemistry, RAK Medical and Health Sciences University, Ras Al Khaimah, 11172, United Arab Emirates.
Department of Pharmaceutical Chemistry, RAK Medical and Health Sciences University, Ras Al Khaimah, 11172, United Arab Emirates; Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar 190006, Jammu and Kashmir, India.
J Genet Eng Biotechnol. 2024 Dec;22(4):100410. doi: 10.1016/j.jgeb.2024.100410. Epub 2024 Aug 22.
The research targeting the prevention of complications through natural constituents, instigated by the cancer has recently drawn much more attention over the globe. The research in this direction also revealed that the use of natural constituents would considered a promising strategy for diminishing the aforementioned disease and its consequences. Because of the easy availability and safe nature, the recent years, natural resources as strong anticancer agents. In this regard, here we introduced the possibility of using the methanolic extract of Physalis angulata root as a strong candidate and implemented the applicability of LC-MS to unveil the presence of various phytocompounds. The anticancer potential exhibited by Physalis angulata root followed by its ability to induce toxicity against the microbial population enhanced the interest in unveiling the phytochemical compounds including Absintholide, Curcumin dimer 1, Mytilin A, Ginsenoside F1, Encecalin , Ganoderic acid TQ, Alnustone, Rhamnetin 3-sophoroside, Gibberellin A14 aldehyde, Thiolutin, Euglobal III and Epomusenin B. The presence of various macro and micronutrients suggested that Physalis angulata is a prominent resource for future research targeting pharmacological research, especially anticancer research.
近年来，由癌症引发的、旨在通过天然成分预防并发症的研究在全球范围内引起了更多关注。这方面的研究还表明，使用天然成分将被视为减轻上述疾病及其后果的一种有前景的策略。由于易于获取且性质安全，近年来自然资源被视为强大的抗癌剂。在这方面，我们在此介绍了使用酸浆根甲醇提取物作为有力候选物的可能性，并应用液相色谱 - 质谱联用技术（LC - MS）来揭示各种植物化合物的存在。酸浆根展现出的抗癌潜力，以及其对微生物群体的毒性诱导能力，增强了人们对揭示包括苦艾内酯、姜黄素二聚体1、贻贝素A、人参皂苷F1、恩卡林、灵芝酸TQ、桤木酮、鼠李素3 - 槐糖苷、赤霉素A14醛、硫藤黄素、优降糖Ⅲ和埃波木宁B等植物化学化合物的兴趣。各种大量和微量营养素的存在表明，酸浆是未来针对药理学研究，尤其是抗癌研究的重要资源。
