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实时触发外骨骼的时空脊髓刺激恢复行走能力：一例报告

Spatiotemporal spinal cord stimulation with real-time triggering exoskeleton restores walking capability: a case report.

作者信息

Liu Penghao, Cheng Yuanchen, Xu Zhuofan, Li Xiaoyu, Chen Zan, Duan Wanru

机构信息

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Lab of Spinal Cord Injury and Functional Reconstruction, China International Neuroscience Institute (CHNA-INI), Beijing, China.

出版信息

Ann Clin Transl Neurol. 2025 Mar;12(3):659-665. doi: 10.1002/acn3.52281. Epub 2024 Dec 15.

DOI:10.1002/acn3.52281
PMID:39675019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11920746/
Abstract

OBJECTIVE

Motor recovery is challenging for spinal cord injury (SCI), especially in low-level SCI.

METHODS

A 16-year-old patient with complete SCI at T12 presented flaccid paralysis and inability to control defecation and was scored as ASIA A at admission. The patient underwent spinal cord stimulation (SCS) implantation at the T11-L1, followed by an innovative algorithm combining spatiotemporal SCS with real-time triggered exoskeleton training (EXS-SCS).

RESULTS

After 1 month of treatment, she gained substantial improvement in her iliopsoas and quadriceps femoris muscle strength to grade 3-4 as well as percutaneous EMG, allowing for assisted standing and walking, and was reassessed as ASIA C.

INTERPRETATION

This case reveals the potential of SCS-EXS regimen in restoring walking capability of SCI patients.

摘要

目的

脊髓损伤（SCI）后的运动功能恢复具有挑战性，尤其是在低位SCI患者中。

方法

一名16岁的T12完全性SCI患者表现为弛缓性瘫痪且无法控制排便，入院时ASIA分级为A级。该患者在T11-L1节段接受了脊髓刺激（SCS）植入，随后采用了一种创新算法，将时空SCS与实时触发的外骨骼训练（EXS-SCS）相结合。

结果

经过1个月的治疗，她的髂腰肌和股四头肌肌力显著改善至3-4级，经皮肌电图也有改善，能够辅助站立和行走，重新评估为ASIA C级。

解读

该病例揭示了SCS-EXS方案在恢复SCI患者步行能力方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/478d/11920746/61f635593b3f/ACN3-12-659-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/478d/11920746/87a09527c222/ACN3-12-659-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/478d/11920746/c07f318a358b/ACN3-12-659-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/478d/11920746/61f635593b3f/ACN3-12-659-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/478d/11920746/87a09527c222/ACN3-12-659-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/478d/11920746/c07f318a358b/ACN3-12-659-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/478d/11920746/61f635593b3f/ACN3-12-659-g001.jpg

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