Sun Jingwei, Yuan Huimin, Yu Yanru, Li Aorou, Zhao Zihe, Tang Yang, Zheng Fengjie
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Front Immunol. 2024 Nov 29;15:1456875. doi: 10.3389/fimmu.2024.1456875. eCollection 2024.
Primary cilia (PC) are essential signaling hubs for proper epithelial formation and the maintenance of skin homeostasis. Found on most cells in the human body, including skin cells, PC facilitate signal transduction that allows ciliated cells to interact with the immune system via multiple pathways, helping to maintain immune system homeostasis. PC can be altered by various microenvironmental stimuli to develop corresponding regulatory functions. Both PC and ciliary signaling pathways have been shown to be involved in the immune processes of various skin lesions. However, the mechanisms by which PC regulate cellular functions and maintain immune homeostasis in tissues are highly complex, and our understanding of them in the skin remains limited. In this paper, we discuss key ciliary signaling pathways and ciliated cells in the skin, with a focus on their immunomodulatory functions. We have compiled evidence from various cells, tissues and disease models to help explore the potential immunomodulatory effects of PC in the skin and their molecular mechanisms.
原发性纤毛（PC）是上皮正常形成和皮肤内稳态维持所必需的信号枢纽。PC存在于人体大多数细胞上，包括皮肤细胞，它促进信号转导，使纤毛细胞能够通过多种途径与免疫系统相互作用，有助于维持免疫系统的内稳态。PC可被各种微环境刺激改变，从而发挥相应的调节功能。PC和纤毛信号通路均已被证明参与了各种皮肤损伤的免疫过程。然而，PC调节细胞功能和维持组织内免疫稳态的机制非常复杂，我们对其在皮肤中的了解仍然有限。在本文中，我们讨论了皮肤中的关键纤毛信号通路和纤毛细胞，重点关注它们的免疫调节功能。我们汇集了来自各种细胞、组织和疾病模型的证据，以帮助探索PC在皮肤中的潜在免疫调节作用及其分子机制。
