da Costa Pedro Henrique, Ferreira Nathalia Dos Santos, Nogueira Ana Rita de Araujo, Azevedo Eduardo Bessa, Gonzalez Mario Henrique
National Institute for Alternative Technologies for Detection, Toxicological Assessment and Removal of Emerging Micropollutants and Radioactives (INCT-DATREM), Department of Chemistry and Environmental Science, São Paulo State University (UNESP), São José do Rio Preto, SP, 15054-000, Brazil.
Environmental Technologies Development Laboratory (LDTAmb), São Carlos Institute of Chemistry, University of São Paulo (USP), São Carlos, SP, 13566-690, Brazil.
ACS Omega. 2024 Nov 22;9(49):48315-48322. doi: 10.1021/acsomega.4c06165. eCollection 2024 Dec 10.
Selenium is one of the most important trace element micronutrients for the global biota, mainly due to its role in protecting against oxidative stress. However, this element can become toxic when present at concentrations slightly higher than those needed for metabolic purposes. It can be transferred through the food chain toward higher trophic levels, with bioaccumulation and biomagnification leading to possible toxicity. This study investigates the bioconcentration and toxicity potential of Se(IV) in Nile tilapia (). After 7 days of exposure, Se concentrations in the fish tissues were in the order: liver ≫ stomach > gills > muscle. In bioconcentration tests, the uptake constant ( ) ranged from 0.34 to 4.68 mL g d, while the clearance rate constant ( ) ranged from 0.12 to 0.36 d. The tissues presented high bioconcentration factors (BCF) ranging from 2.67 to 12.73, demonstrating the ability of Se(IV) to concentrate in muscle, gills, and stomach. Although the data for the liver could not be fitted by the model used, the measured Se(IV) concentrations were approximately six times higher than those found for the stomach, indicating that the , , and BCF values were very high. Estimated LC values lower than 10 mg L suggested that Se(IV) could be considered very toxic to the fish.
硒是全球生物群最重要的微量元素营养素之一，主要是因为它在抵御氧化应激方面发挥作用。然而，当该元素的浓度略高于代谢所需浓度时，就会产生毒性。它可以通过食物链向更高营养级转移，生物累积和生物放大作用可能导致毒性。本研究调查了尼罗罗非鱼中硒（IV）的生物富集和潜在毒性。暴露7天后，鱼组织中的硒浓度顺序为：肝脏≫胃＞鳃＞肌肉。在生物富集试验中，摄取常数（ ）范围为0.34至4.68 mL g⁻¹ d⁻¹，而清除率常数（ ）范围为0.12至0.36 d⁻¹。这些组织呈现出较高的生物富集系数（BCF），范围为2.67至12.73，表明硒（IV）能够在肌肉、鳃和胃中富集。尽管肝脏的数据无法用所使用的模型拟合，但测得的硒（IV）浓度大约是胃中浓度的六倍，这表明 、 和BCF值非常高。估计的LC值低于10 mg L⁻¹，表明硒（IV）对鱼类具有很高的毒性。
