College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin, 130118, China; Ministry of Education Laboratory of Animal Production and Quality Security, Jilin Agricultural University, Changchun, Jilin, 130118, China; Joint Laboratory of Modern Agricultural Technology International Cooperation, Ministry of Education, Jilin Agricultural University, Changchun, Jilin, 130118, China; Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, Jilin Agricultural University, Changchun, Jilin, 130118, China.
Freshwater Fisheries Research Institute of Jilin Province, Changchun, Jilin, 130000, China.
Chemosphere. 2020 Apr;244:125546. doi: 10.1016/j.chemosphere.2019.125546. Epub 2019 Dec 4.
Selenium (Se) is the most common micronutrient and that becomes toxic when present at higher concentrations in aquatic environments. Astaxanthin (AST) has been documented to possess antioxidant and anti-inflammatory properties. The aim of this study was to explore the potential of dietary AST and Se exposure on oxidative stress, and inflammatory response in Channa argus. After acclimation, 540 fish were randomly distributed into nine groups housed in twenty-seven glass tanks. The fish were exposed for 8 weeks to waterborne Se at 0, 100 and 200 μg L or dietary AST at 0, 50 and 100 mg kg. The results shown that Se accumulation in the kidney, liver, spleen, intestine and gill were significantly increased following Se exposure, dietary 50 and 100 mg kg AST supplementation decreased the accumulation of Se in the kidney, liver, spleen, and intestine. In addition, AST supplementation can decrease oxidative stress and inflammatory response in the liver and spleen following exposure to waterborne Se. These results indicate that AST has the potential to alleviate the effects of Se toxicity in C. argus.
硒（Se）是最常见的微量元素，当它在水生环境中以更高的浓度存在时就会变得有毒。虾青素（AST）已被证明具有抗氧化和抗炎特性。本研究旨在探索饮食中 AST 和 Se 暴露对乌鳢（Channa argus）氧化应激和炎症反应的潜在影响。经过适应期后，将 540 条鱼随机分配到 27 个玻璃缸中的 9 个组中。这些鱼在水中暴露 8 周，接触的 Se 浓度分别为 0、100 和 200μg/L，或通过饮食摄入 AST 浓度分别为 0、50 和 100mg/kg。结果表明，暴露于 Se 后，肾脏、肝脏、脾脏、肠道和鳃中的 Se 积累明显增加，膳食中补充 50 和 100mg/kg AST 可减少肾脏、肝脏、脾脏和肠道中 Se 的积累。此外，AST 补充剂可降低水暴露后肝脏和脾脏的氧化应激和炎症反应。这些结果表明，AST 有可能减轻 C. argus 中 Se 毒性的影响。
