Vass Lindsay K, Copara Milagros S, Seyal Masud, Shahlaie Kiarash, Farias Sarah Tomaszewski, Shen Peter Y, Ekstrom Arne D
Center for Neuroscience, University of California, Davis, 1 Shields Avenue, Davis, CA 95618, USA.
Department of Neurology, University of California, Davis Medical Center, 4860 Y Street, Suite 0100, Sacramento, CA 95817, USA.
Neuron. 2016 Mar 16;89(6):1180-1186. doi: 10.1016/j.neuron.2016.01.045. Epub 2016 Feb 25.
Low-frequency (delta/theta band) hippocampal neural oscillations play prominent roles in computational models of spatial navigation, but their exact function remains unknown. Some theories propose they are primarily generated in response to sensorimotor processing, while others suggest a role in memory-related processing. We directly recorded hippocampal EEG activity in patients undergoing seizure monitoring while they explored a virtual environment containing teleporters. Critically, this manipulation allowed patients to experience movement through space in the absence of visual and self-motion cues. The prevalence and duration of low-frequency hippocampal oscillations were unchanged by this manipulation, indicating that sensorimotor processing was not required to elicit them during navigation. Furthermore, the frequency-wise pattern of oscillation prevalence during teleportation contained spatial information capable of classifying the distance teleported. These results demonstrate that movement-related sensory information is not required to drive spatially informative low-frequency hippocampal oscillations during navigation and suggest a specific function in memory-related spatial updating.
低频（δ/θ频段）海马体神经振荡在空间导航的计算模型中起着重要作用，但其确切功能尚不清楚。一些理论认为它们主要是在对感觉运动处理做出反应时产生的，而另一些理论则认为它们在与记忆相关的处理中发挥作用。我们在癫痫监测患者探索包含传送器的虚拟环境时，直接记录了他们的海马体脑电图活动。至关重要的是，这种操作使患者在没有视觉和自我运动线索的情况下体验空间中的移动。这种操作并未改变低频海马体振荡的发生率和持续时间，这表明在导航过程中引发这些振荡不需要感觉运动处理。此外，传送过程中振荡发生率的频率模式包含能够对传送距离进行分类的空间信息。这些结果表明，在导航过程中驱动具有空间信息的低频海马体振荡不需要与运动相关的感觉信息，并暗示了在与记忆相关的空间更新中的特定功能。
