Novel statistically equivalent signature-based hybrid feature selection and ensemble deep learning LSTM and GRU for chronic kidney disease classification.

Chronic kidney disease (CKD) involves numerous variables, but only a few significantly impact the classification task. The statistically equivalent signature (SES) method, inspired by constraint-based learning of Bayesian networks, is employed to identify essential features in CKD. Unlike conventional feature selection methods, which typically focus on a single set of features with the highest predictive potential, the SES method can identify multiple predictive feature subsets with similar performance. However, most feature selection (FS) classifiers perform suboptimally with strongly correlated data. The FS approach faces challenges in identifying crucial features and selecting the most effective classifier, particularly in high-dimensional data. This study proposes using the Least Absolute Shrinkage and Selection Operator (LASSO) in conjunction with the SES method for feature selection in CKD identification. Following this, an ensemble deep-learning model combining long short-term memory (LSTM) and gated recurrent unit (GRU) networks is proposed for CKD classification. The features selected by the hybrid feature selection method are fed into the ensemble deep-learning model. The model's performance is evaluated using accuracy, precision, recall, and F1 score metrics. The experimental results are compared with individual classifiers, including decision tree (DT), Random Forest (RF), logistic regression (LR), and support vector machine (SVM). The findings indicate a 2% improvement in classification accuracy when using the proposed hybrid feature selection method combined with the LSTM and GRU ensemble deep-learning model. Further analysis reveals that certain features, such as HEMO, POT, bacteria, and coronary artery disease, contribute minimally to the classification task. Future research could explore additional feature selection methods, including dynamic feature selection that adapts to evolving datasets and incorporates clinical knowledge to enhance CKD classification accuracy further.