慢性肾衰竭患者血清II组胃蛋白酶原浓度与十二指肠腺增生程度的关系。
Relation between serum group II pepsinogen concentration and the degree of Brunner's gland hyperplasia in patients with chronic renal failure.
作者信息
Paimela H, Härkönen M, Karonen S L, Tallgren L G, Stenman S, Ahonen J
出版信息
Gut. 1985 Feb;26(2):198-202. doi: 10.1136/gut.26.2.198.
Serum concentrations of group I and II pepsinogens (PG I and PG II) were determined in 15 patients with chronic renal failure. Gastroduodenoscopy with biopsy and acid secretion tests were also performed. Five patients had histologically confirmed severe Brunner's gland hyperplasia manifesting as multiple polyps in the duodenal bulb. Five patients had a mild form of Brunner's gland hyperplasia which was evident only by histological analysis. Five had no signs of such alterations. The three groups of patients were comparable in age, sex, mean level of serum creatinine, mean duration of dialysis treatment, distribution of non-dialysed and dialysed patients, and gastric histology. In patients with severe Brunner's gland hyperplasia the mean serum PG II concentration was significantly higher than in the other patients. Both the serum PG I and the serum PG II concentrations decreased after receiving a well functioning renal transplant in the two patients who underwent transplantation.
测定了15例慢性肾功能衰竭患者血清中I组和II组胃蛋白酶原（PG I和PG II）的浓度。还进行了胃镜活检及胃酸分泌试验。5例患者经组织学证实有严重的Brunner腺增生，表现为十二指肠球部多发息肉。5例患者有轻度Brunner腺增生，仅通过组织学分析才明显。5例无此类改变迹象。三组患者在年龄、性别、血清肌酐平均水平、透析治疗平均时长、未透析和透析患者分布以及胃组织学方面具有可比性。严重Brunner腺增生患者的血清PG II平均浓度显著高于其他患者。接受移植的2例患者在接受功能良好的肾移植后，血清PG I和血清PG II浓度均下降。
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