磁性发光纳米粒子FeO@LaF:Eu,Ag@APTES@β-CD的合成，一种潜在的抗菌药物环丙沙星载体。
Synthesis of Magnetic Luminescent Nanoparticle FeO@LaF:Eu,Ag@APTES@β-CD, a Potential Carrier of Antimicrobial Drug Ciprofloxacin.
作者信息
Swain Sangita Kumari, Phaomei Ganngam, Dash Sandip Kumar, Tripathy Sukanta Kumar
机构信息
Center of Excellence in Nanoscience and Technology for Development of Sensors (CoENSTds), Berhampur University, Ganjam, Odisha 760007 India.
Department of Chemistry, Berhampur University, Berhampur, Ganjam, Odisha 760007 India.
出版信息
Indian J Microbiol. 2024 Dec;64(4):1637-1645. doi: 10.1007/s12088-024-01202-z. Epub 2024 Feb 8.
FeO@LaF:Eu,Ag hybrid magnetic luminescent nanoparticles (NPs) were synthesized using a simple co-precipitation method and then functionalized with β-cyclodextrin (β-CD) using (3-aminopropyl)triethoxysilane (APTES). The chemical composition, crystalline nature, particle size, and surface morphology of the FeO@LaF:Eu,Ag@APTES@β-CD NPs were investigated, using powder X-ray diffraction, and high-resolution transmission electron microscopy. The uptake and release profiling of the LaF:Eu,Ag@FeO@β-CD NPs for the hydrophilic drug ciprofloxacin, showed 40 and 85% efficiency, respectively. The results indicated that the NPs have a high drug loading yield and a sustained drug releasing profile of the NPs, indicating that they can be used as a drug carrier. The photoluminescence spectral analysis of the NPs revealed their potentiality for use in bioimaging. Further analysis of the drug-loaded NPs (FeO@LaF:Eu,Ag@APTES@β-CD-ciprofloxacin) revealed, 100% microbial inhibition efficiency against and , and a minimum of 80% against .
采用简单的共沉淀法合成了FeO@LaF:Eu,Ag杂化磁性发光纳米粒子（NPs），然后使用（3-氨丙基）三乙氧基硅烷（APTES）用β-环糊精（β-CD）对其进行功能化。利用粉末X射线衍射和高分辨率透射电子显微镜对FeO@LaF:Eu,Ag@APTES@β-CD NPs的化学成分、晶体性质、粒径和表面形态进行了研究。LaF:Eu,Ag@FeO@β-CD NPs对亲水性药物环丙沙星的摄取和释放曲线分别显示出40%和85%的效率。结果表明，这些纳米粒子具有较高的载药量和持续的药物释放曲线，表明它们可作为药物载体。纳米粒子的光致发光光谱分析揭示了它们在生物成像中的应用潜力。对载药纳米粒子（FeO@LaF:Eu,Ag@APTES@β-CD-环丙沙星）的进一步分析显示，对[具体微生物1]和[具体微生物2]的抑菌效率为100%，对[具体微生物3]的抑菌效率至少为80%。
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