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Ocular penetration of (125I)IVDU, a radiolabeled analogue of bromovinyldeoxyuridine.

作者信息

Maudgal P C, Verbruggen A M, De Clercq E, Busson R, Bernaerts R, de Roo M, Ameye C, Missotten L

出版信息

Invest Ophthalmol Vis Sci. 1985 Jan;26(1):45-9.

PMID:3967955
Abstract

Following topical application of (125)IVDU, the radiolabeled analogue of bromovinyldeoxyuridine ([E]-5-[2-bromovinyl]-2'-deoxyuridine), as 0.5% or 0.3% eyedrops, to rabbits, (125I)IVDU appeared in the anterior chamber fluid at drug levels well above the minimum concentration (0.01 microgram/mL) required for inhibition of herpes simplex virus type 1 replication. These findings are consistent with the efficacy of 0.5% bromovinyldeoxyuridine eyedrops in the topical treatment of herpes simplex uveitis.

摘要

相似文献

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引用本文的文献

1
Specific neuro-radiological diagnosis of herpes encephalitis in an animal model.
Arch Virol. 1988;101(1-2):1-12. doi: 10.1007/BF01314647.
2
Bromovinyldeoxyuridine and interferon treatment in ulcerative herpetic keratitis: a double masked study.溴乙烯基脱氧尿苷与干扰素治疗溃疡性疱疹性角膜炎：一项双盲研究。
Br J Ophthalmol. 1989 Aug;73(8):604-7. doi: 10.1136/bjo.73.8.604.
3
Topical BVDU plus low-dosage steroids in the treatment of chronic relapsing zoster keratouveitis. A pilot study.局部应用BVDU联合低剂量类固醇治疗慢性复发性带状疱疹性角膜葡萄膜炎：一项初步研究
Graefes Arch Clin Exp Ophthalmol. 1989;227(2):118-22. doi: 10.1007/BF02169782.