1990 - 2021年204个国家和地区的胆管癌疾病负担：2021年全球疾病负担研究的全面人口分析

Disease burden of biliary tract cancer in 204 countries and territories, 1990-2021: A comprehensive demographic analysis of the Global Burden of Disease Study 2021.

作者信息

Sun Xuheng, Liu Jiangmei, Zhang Wei, Wang Yijun, Jiang Yan, Wang Lijun, Zou Yixin, Xiao Yuxuan, Xiang Yongbing, Li Maolan, Zhou Maigeng, Liu Yingbin

机构信息

Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200120, China.

National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

出版信息

Chin Med J (Engl). 2024 Dec 20;137(24):3117-3125. doi: 10.1097/CM9.0000000000003395. Epub 2024 Dec 17.

DOI:10.1097/CM9.0000000000003395

PMID:39682017

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11706591/

Abstract

BACKGROUND

Biliary tract carcinomas (BTCs) are relatively rare but lethal primary malignant tumors derived from the biliary tract system. The burden of BTCs varies according to sex, age, region, and country, but limited attention has been paid to the burden of BTCs. We sought to explore the up-to-date data from the Global Burden of Disease Study (GBD) and expand findings by accessing the demographic features of BTC disease burden.

METHODS

Using the latest data from the GBD 2021, we evaluated and analyzed the distributions and patterns of BTC disease burden in various age groups, sexes, regions, and countries.

RESULTS

The number of incident cases, deaths, and disability-adjusted life-years (DALYs) tended to increase and peaked at 216,770 (95% uncertainty interval [UI]: 181,890-245,240), 171,960 (95% UI: 142,350-194,240), and 3,732,100 (95% UI: 3,102,900-4,317,000) person-years, respectively, in 2021. However, the average global age-standardized rates (ASRs) of incident cases, deaths, and DALYs shrunk by -11.46% (95% UI: -21.91 to 3.35%), -24.09% (95% UI: -33.19 to 16.88%), and -26.25% (95% UI: -35.53 to 18.36%), respectively, from 1990 to 2021. Meanwhile, the male/female ratio (male per 100 female) of incidence, deaths, and DALYs changed from 76.40, 75.41, and 74.72 to 86.89, 79.11, and 82.29, respectively. In 2021, the highest number of incident cases, deaths, and DALYs occurred in East Asia. The top three highest incidences, deaths, and DALYs were observed in China, India, and Japan, and the highest ASRs were observed in Chile in 2021. Analysis of the Human Development Index along with disease burden estimates of BTCs also suggests that the burden of the disease is related to the level of comprehensive development of the society.

CONCLUSION

This study provided a comprehensive comparison of differences in the burden of disease across populations and over time, and further presented evidence concerning the formulation of prevention and control policies and etiologic studies for BTCs and proposed logical hypotheses to investigate.

摘要

背景

胆管癌（BTCs）是源自胆道系统的相对罕见但致命的原发性恶性肿瘤。BTCs的疾病负担因性别、年龄、地区和国家而异，但对其疾病负担的关注有限。我们试图探索全球疾病负担研究（GBD）的最新数据，并通过了解BTC疾病负担的人口统计学特征来扩展研究结果。

方法

使用GBD 2021的最新数据，我们评估并分析了BTC疾病负担在不同年龄组、性别、地区和国家的分布及模式。

结果

2021年，新发病例数、死亡数和伤残调整生命年（DALYs）呈上升趋势，并分别在216,770例（95%不确定区间[UI]：181,890 - 245,240）、171,960例（95% UI：142,350 - 194,240）和3,732,100人年（95% UI：3,102,900 - 4,317,000）达到峰值。然而，从1990年到2021年，全球新发病例、死亡和DALYs的平均年龄标准化率（ASRs）分别下降了-11.46%（95% UI：-21.91至3.35%）、-24.09%（95% UI：-33.19至16.88%）和-26.25%（95% UI：-35.53至18.36%）。同时，发病率、死亡率和DALYs的男/女比例（每100名女性对应的男性数）分别从76.40、75.41和74.72变为86.89、79.11和82.29。2021年，东亚地区的新发病例数、死亡数和DALYs最多。中国、印度和日本的发病率、死亡率和DALYs位列前三，2021年智利的ASRs最高。对人类发展指数与BTCs疾病负担估计的分析还表明，该疾病的负担与社会综合发展水平相关。