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血清素对屏状核投射神经元的抑制作用：离子机制、受体亚型及对屏状核计算的影响

Serotonin Inhibition of Claustrum Projection Neurons: Ionic Mechanism, Receptor Subtypes and Consequences for Claustrum Computation.

作者信息

Wong Kelly Li Lin, Graf Martin, Augustine George J

机构信息

Neuroscience & Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.

Temasek Life Sciences Laboratory, Singapore 117604, Singapore.

出版信息

Cells. 2024 Nov 29;13(23):1980. doi: 10.3390/cells13231980.

DOI:10.3390/cells13231980
PMID:39682728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11640313/
Abstract

The claustrum is a small but densely interconnected brain structure that is innervated by axons containing serotonin (5-HT), a neuromodulator that has been implicated in control of sleep and in the actions of psychedelic drugs. However, little is known about how 5-HT influences the claustrum. We have combined whole-cell patch-clamp measurements of ionic currents, flash photolysis, and receptor pharmacology to characterize the 5-HT responses of individual claustral projection neurons (PNs) in mouse brain slices. Serotonin application elicited a long-lasting outward current in claustral PNs. This current was due to an increase in membrane permeability to K ions and was mediated mainly by the type 1A 5-HT receptor (5-HTR-1A). The 5-HT-induced K current hyperpolarized, and thereby inhibited, the PNs by reducing action potential firing. Focal uncaging of 5-HT revealed that inhibitory 5-HTR-1As were located at both the soma and dendrites of PNs. We conclude that 5-HT creates a net inhibition in the claustrum, an action that should decrease claustrum sensitivity to excitatory input from other brain areas and thereby contribute to 5-HT action in the brain.

摘要

屏状核是一个小而紧密相连的脑结构，它由含有血清素（5-羟色胺，5-HT）的轴突支配，血清素是一种神经调质，与睡眠控制和致幻药物的作用有关。然而，关于5-HT如何影响屏状核，人们知之甚少。我们结合了离子电流的全细胞膜片钳测量、闪光光解和受体药理学，以表征小鼠脑片中单个屏状核投射神经元（PNs）的5-HT反应。应用血清素可在屏状核PNs中引发持久的外向电流。该电流是由于细胞膜对钾离子的通透性增加所致，主要由1A型5-HT受体（5-HTR-1A）介导。5-HT诱导的钾电流使PNs超极化，从而通过减少动作电位发放来抑制PNs。5-HT的局部光解显示，抑制性5-HTR-1A位于PNs的胞体和树突上。我们得出结论，5-HT在屏状核中产生净抑制作用，这一作用应会降低屏状核对来自其他脑区兴奋性输入的敏感性，从而有助于5-HT在大脑中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/a0a9360384f2/cells-13-01980-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/2b2851c8e4d6/cells-13-01980-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/a1dc9ff0b43b/cells-13-01980-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/22360acfc1b8/cells-13-01980-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/548ceec16c94/cells-13-01980-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/2672eab0b8b1/cells-13-01980-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/47783ddc6a81/cells-13-01980-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/7a5f4b6a0e86/cells-13-01980-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/a00ed7f0f085/cells-13-01980-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/b87870a9206a/cells-13-01980-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/a0a9360384f2/cells-13-01980-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/2b2851c8e4d6/cells-13-01980-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/a1dc9ff0b43b/cells-13-01980-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/22360acfc1b8/cells-13-01980-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/548ceec16c94/cells-13-01980-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/2672eab0b8b1/cells-13-01980-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/47783ddc6a81/cells-13-01980-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/7a5f4b6a0e86/cells-13-01980-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/a00ed7f0f085/cells-13-01980-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/b87870a9206a/cells-13-01980-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74ce/11640313/a0a9360384f2/cells-13-01980-g010.jpg

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Nat Commun. 2024 Sep 18;15(1):8176. doi: 10.1038/s41467-024-52429-9.
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Distinct 5-HT receptor subtypes regulate claustrum excitability by serotonin and the psychedelic, DOI.不同的 5-HT 受体亚型通过血清素和迷幻剂 DOI 调节屏状核的兴奋性。
Prog Neurobiol. 2024 Sep;240:102660. doi: 10.1016/j.pneurobio.2024.102660. Epub 2024 Aug 31.
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Claustrum neurons projecting to the anterior cingulate restrict engagement during sleep and behavior.
投射到扣带回前部的屏状核神经元限制睡眠和行为期间的参与。
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The claustrum and consciousness: An update.屏状核与意识：最新进展
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A functional logic for neurotransmitter corelease in the cholinergic forebrain pathway.胆碱能前脑通路中神经递质共释放的功能逻辑。
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