Lechkova Borislava, Shishmanova-Doseva Michaela, Benbassat Niko, Gevrenova Reneta, Atanassova Pepa, Penkova Nadya, Peychev Lyudmil, Hrischev Petar, Peychev Zhivko, Ivanova Stanislava
Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Research Institute, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Molecules. 2024 Dec 4;29(23):5723. doi: 10.3390/molecules29235723.
L. has been traditionally applied as a remedy for headaches, rheumatism, digestion, respiratory and neurological problems, and other medical conditions. However, the literature data on its effects on cognitive function are scarce. The aim of the present work was to evaluate the effects of two doses of alcohol extract on cognitive functions, hippocampal brain-derived neurotrophic factor (BDNF) expression, and organ toxicity in rats. Rats were treated with 200 mg/kg (TV 200) and 1000 mg/kg (TV 1000) for 28 days. After one week of pre-treatment, the animals were subjected to a series of tests. We found that in the active avoidance test, only TV 200 improved learning and memory, while in the passive avoidance test, both doses facilitated these processes. In addition, the two doses enhanced spatial memory. In the elevated plus maze test, only the higher dose of TV 1000 resulted in anxiolytic-like behavior. Both doses of the extract significantly increased the hippocampal expression of BDNF. We suggest that increased neurotrophic factor expression could be one of the important mechanisms underlying the cognition-enhancing effects of extract.
传统上，L. 一直被用作治疗头痛、风湿、消化、呼吸和神经问题以及其他病症的药物。然而，关于其对认知功能影响的文献数据却很稀少。本研究的目的是评估两种剂量的酒精提取物对大鼠认知功能、海马脑源性神经营养因子（BDNF）表达及器官毒性的影响。大鼠分别用200 mg/kg（TV 200）和1000 mg/kg（TV 1000）处理28天。预处理一周后，对动物进行一系列测试。我们发现，在主动回避试验中，只有TV 200改善了学习和记忆，而在被动回避试验中，两种剂量均促进了这些过程。此外，两种剂量均增强了空间记忆。在高架十字迷宫试验中，只有较高剂量的TV 1000产生了抗焦虑样行为。两种剂量的提取物均显著增加了海马中BDNF的表达。我们认为，神经营养因子表达的增加可能是提取物增强认知作用的重要机制之一。
