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在组合磁场下佛波醇肉豆蔻酸酯乙酸酯与酒精水溶液之间的非接触相互作用

Non-Contact Interaction Between Phorbol Myristate Acetate and Aqueous Alcohol Solutions Under Combined Magnetic Fields.

作者信息

Novikov Vadim V, Yablokova Elena V, Stepanov German O, Rodionova Natalia N, Tarasov Sergey A, Buravleva Ekaterina V, Yablonskaya Olga I, Voeikov Vladimir L

机构信息

Institute of Cell Biophysics of the Russian Academy of Sciences, 142290 Pushchino, Russia.

OOO «NPF «Materia Medica Holding», 129272 Moscow, Russia.

出版信息

Molecules. 2024 Dec 9;29(23):5814. doi: 10.3390/molecules29235814.


DOI:10.3390/molecules29235814
PMID:39683970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11643221/
Abstract

Previous research has demonstrated that a combined magnetic field (CMF) plays a critical role in modifying the properties of aqueous solutions, leading to an increase in the luminol-enhanced chemiluminescence of neutrophils. Using this model, the distant interaction between aqueous solutions was demonstrated, and the role of a CMF in the regulation of this phenomenon was established. In the current study, highly diluted (HD) phorbol myristate acetate (PMA) solution (the donor) was incubated with aqueous ethanol (the acceptor), both in a CMF-generating device and under geomagnetic field (GMF), for 0, 20, and 60 min. After a 60 min incubation at a 0 cm distance with HD PMA under both GMF and CMF, acceptor samples added to neutrophils increased neutrophil chemiluminescence by approximately sevenfold. The ability of HD PMA, which had been incubated with an acceptor, to activate ROS production diminished within 60 min of observation. However, the HD PMA sample remained an effective donor for up to 6 days after preparation. At a 10 cm distance between the donor and acceptor, the activation of the acceptor did not occur. These findings provide new insights into the phenomenon of distant interaction of solutions, whose mechanisms are suggested to be related to the quantum electrodynamics of water molecular dynamic structures.

摘要

先前的研究表明,组合磁场(CMF)在改变水溶液性质方面起着关键作用,导致中性粒细胞的鲁米诺增强化学发光增加。利用该模型,证明了水溶液之间的远距离相互作用,并确立了CMF在调节这一现象中的作用。在当前研究中,将高稀释(HD)的佛波酯(PMA)溶液(供体)与乙醇水溶液(受体)在产生CMF的装置中以及在地磁场(GMF)下孵育0、20和60分钟。在GMF和CMF下,HD PMA在0厘米距离处孵育60分钟后,添加到中性粒细胞中的受体样品使中性粒细胞化学发光增加了约7倍。与受体孵育后的HD PMA激活ROS产生的能力在观察的60分钟内减弱。然而,HD PMA样品在制备后长达6天仍是有效的供体。在供体和受体之间距离为10厘米时,受体未被激活。这些发现为溶液远距离相互作用现象提供了新的见解,其机制被认为与水分子动态结构的量子电动力学有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/2e5ff8e03d6e/molecules-29-05814-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/79187df67dfb/molecules-29-05814-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/f887882113f8/molecules-29-05814-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/47d29006c267/molecules-29-05814-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/8b75b4f9a4f7/molecules-29-05814-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/3d572c09aa9a/molecules-29-05814-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/826211e15005/molecules-29-05814-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/94a720f0b465/molecules-29-05814-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/2e5ff8e03d6e/molecules-29-05814-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/79187df67dfb/molecules-29-05814-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/f887882113f8/molecules-29-05814-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/47d29006c267/molecules-29-05814-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/8b75b4f9a4f7/molecules-29-05814-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/3d572c09aa9a/molecules-29-05814-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/826211e15005/molecules-29-05814-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/94a720f0b465/molecules-29-05814-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3506/11643221/2e5ff8e03d6e/molecules-29-05814-g008.jpg

相似文献

[1]
Non-Contact Interaction Between Phorbol Myristate Acetate and Aqueous Alcohol Solutions Under Combined Magnetic Fields.

Molecules. 2024-12-9

[2]
Reactive oxygen species (ROS) production in human peripheral blood neutrophils exposed in vitro to static magnetic field.

Electromagn Biol Med. 2013-12

[3]
Activation of human neutrophils by electronically transmitted phorbol-myristate acetate.

Med Hypotheses. 2000-1

[4]
Effect of interferon-alpha on production of reactive oxygen species by human neutrophils.

Luminescence. 2001

[5]
Evaluation of assays for the measurement of bovine neutrophil reactive oxygen species.

Vet Immunol Immunopathol. 2007-1-15

[6]
Activation of equine neutrophils by phorbol myristate acetate or N-formyl-methionyl-leucyl-phenylalanine induces a different response in reactive oxygen species production and release of active myeloperoxidase.

Vet Immunol Immunopathol. 2009-8-15

[7]
[Human serum albumin modified under oxidative/halogenative stress enhances luminol-dependent chemiluminescence of human neutrophils].

Biofizika. 2013

[8]
The phorbol 12-myristate 13-acetate (PMA)-induced oxidative burst in rat peritoneal neutrophils is increased by a 0.1 mT (60 Hz) magnetic field.

FEBS Lett. 1995-12-4

[9]
Analysis and assessment of the capacity of neutrophils to produce reactive oxygen species in a 96-well microplate format using lucigenin- and luminol-dependent chemiluminescence.

J Immunol Methods. 1997-12-15

[10]
Enterobacter cloacae leukotoxin: modulation of reactive oxidant species generated by neutrophils.

Luminescence. 2001

引用本文的文献

[1]
Theoretical Description of Changes in Conformation and Symmetry of Supramolecular Systems During the Reception of a Molecular Signal.

Int J Mol Sci. 2025-7-3

本文引用的文献

[1]
NADPH oxidase-dependent free radical generation and protein adduct formation in neutrophils.

RSC Adv. 2024-8-7

[2]
Physicochemical Study of the Molecular Signal Transfer of Ultra-High Diluted Antibodies to Interferon-Gamma.

Int J Mol Sci. 2023-7-26

[3]
Antibodies Processed Using High Dilution Technology Distantly Change Structural Properties of IFNγ Aqueous Solution.

Pharmaceutics. 2021-11-4

[4]
Effect of Mechanical Shaking on the Physicochemical Properties of Aqueous Solutions.

Int J Mol Sci. 2020-10-28

[5]
Shaking-Induced Aggregation and Flotation in Immunoglobulin Dispersions: Differences between Water and Water-Ethanol Mixtures.

ACS Omega. 2020-6-12

[6]
Formation and Stability of Bulk Nanobubbles by Vibration.

Langmuir. 2020-3-10

[7]
ION cyclotron resonance: Geomagnetic strategy for living systems?

Electromagn Biol Med. 2019

[8]
Effect of weak combined static and extremely low-frequency alternating magnetic fields on spatial memory and brain amyloid-β in two animal models of Alzheimer's disease.

Electromagn Biol Med. 2018

[9]
Electromagnetic information transfer through aqueous system.

Electromagn Biol Med. 2017

[10]
Transduction of DNA information through water and electromagnetic waves.

Electromagn Biol Med. 2015

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