Abusamak Mohammad, Issa Sara Mazen, Alomari Amal F, Alsalamat Husam A, Haj Ali Nour S, Izmegna Abdallah, Shawashreh Mais, Abu Samak Mahmoud, Abusamak Talal M
Department of Special Surgery, School of Medicine, Al-Balqa Applied University, Al-Salt, Jordan.
Amman Eye Clinic, Amman, Jordan.
Front Med (Lausanne). 2024 Dec 2;11:1485718. doi: 10.3389/fmed.2024.1485718. eCollection 2024.
This study investigated how normal corneal stromal profiles change with age, sex, and corrected intraocular pressure (IOP). A retrospective observational analytical study was conducted in Jordan, employing anterior segment spectral-domain optical coherence tomography AS-OCT, a measured corneal stromal thickness (CST) in 134 eyes across the central 6-mm corneal diameter. People between the ages of 18 and 79 were included, and the mean CST values were linked to age groups, IOP, and cis-gender populations, with the exclusion of certain eye conditions. The central stroma was thinnest at 484.6 (±32.6) μm, contrasting with the outer peripheral superior zone's maximum thickness at 549.3 (±40.6) μm. A positive correlation between CST and the 30-49 age group was noted. In conclusion, this study highlights a centrifugal CST distribution, with the central stroma being the thinnest and the superior stroma being the thickest. AS SD-OCT, employing novel algorithms, proves vital in refractive surgery planning and corneal disease diagnosis. The research offers valuable insights into age, gender, and IOP interactions with corneal stromal characteristics, enhancing clinical strategies for corneal pathologies in the Jordanian population.
本研究调查了正常角膜基质形态如何随年龄、性别和矫正眼压（IOP）而变化。在约旦进行了一项回顾性观察分析研究，采用眼前节谱域光学相干断层扫描（AS-OCT），测量了134只眼睛中央6毫米角膜直径范围内的角膜基质厚度（CST）。纳入了年龄在18至79岁之间的人群，将平均CST值与年龄组、IOP和顺性别群体相关联，排除了某些眼部疾病。中央基质最薄，为484.6（±32.6）μm，而外周上方区域最厚，为549.3（±40.6）μm。注意到CST与30-49岁年龄组之间存在正相关。总之，本研究突出了CST的离心分布，中央基质最薄，上方基质最厚。采用新型算法的AS SD-OCT在屈光手术规划和角膜疾病诊断中至关重要。该研究为年龄、性别和IOP与角膜基质特征的相互作用提供了有价值的见解，增强了约旦人群角膜病变的临床策略。
