Wang Xiaogang, Wu Qiang
Department of Ophthalmology, Affiliated Sixth People's Hospital Shanghai Jiao Tong University, Shanghai, China.
Vet Ophthalmol. 2013 Mar;16(2):130-4. doi: 10.1111/j.1463-5224.2012.01041.x. Epub 2012 Jun 6.
To document the thickness of the central cornea in pigmented rabbits using spectral-domain anterior segment optical coherence tomography (AS-OCT).
Seventeen pigmented rabbits (6 male, 11 female, both eyes) were involved in this study.
Thirty-four eyes from healthy pigmented rabbits underwent a complete ophthalmologic examination, including AS-OCT. Eight radial scans, 6 mm in length and centered on the cornea, were obtained using the AS-OCT. Corneal thickness was automatically calculated using pachymetry software. Measurements were displayed as the mean and standard deviation for each of the 17 regions defined by the software. The regions were the center (1 mm radius, area a), the inner ring (2.5 mm radius, area b), the outer ring (3 mm radius, area c), and the eight radial scan lines in eight directions (Superior (1), SN (2), Nasal (3), IN (4), Inferior (5), IT (6), Temporal (7), ST (8)) with an angle of 45° between each consecutive scan line (a, b 1-8, c 1-8).
There was no statistically significance difference in corneal thickness between gender, eye, and the eight directions (P = 0.804, P > 0.05, P > 0.05). There was a statistical difference between the thickness in areas a, b, and c (P < 0.05). The corneal thickness increased gradually from the center to the periphery of the 6 mm measured. The center corneal thickness was 387 ± 19.8 μm for OD and 384 ± 20.2 μm for OS. The corneal thicknesses of the thinnest point of the right eyes (OD) and the left eyes (OS) were 376 ± 20.2 and 370 ± 16.8 μm, respectively. There was positive correlation between the thinnest point and area a in both the right eyes (r = 0.892, P < 0.001) and the left eyes (r = 0.832, P < 0.001).
This is the first documentation of the rabbit corneal thickness in vivo using the spectral-domain AS-OCT. Pigmented rabbit corneas were almost 150 μm thinner than human corneal values. Gender and eye were not associated with any statistical differences in central corneal thickness in this study.
使用谱域眼前节光学相干断层扫描（AS - OCT）记录有色家兔中央角膜的厚度。
本研究纳入了17只有色家兔（6只雄性，11只雌性，双眼）。
对34只来自健康有色家兔的眼睛进行了全面的眼科检查，包括AS - OCT检查。使用AS - OCT获取8条长度为6 mm且以角膜为中心的径向扫描图像。使用测厚软件自动计算角膜厚度。测量结果以软件定义的17个区域中每个区域的平均值和标准差表示。这些区域包括中心（半径1 mm，区域a）、内环（半径2.5 mm，区域b）、外环（半径3 mm，区域c）以及八个方向上的八条径向扫描线（上方（1）、上鼻侧（2）、鼻侧（3）、下鼻侧（4）、下方（5）、下颞侧（6）、颞侧（7）、上颞侧（8）），相邻扫描线之间的夹角为45°（a、b 1 - 8、c 1 - 8）。
性别、眼别以及八个方向之间的角膜厚度在统计学上无显著差异（P = 0.804，P > 0.05，P > 0.05）。区域a、b和c的厚度之间存在统计学差异（P < 0.05）。在所测量的6 mm范围内，角膜厚度从中心到周边逐渐增加。右眼（OD）的中央角膜厚度为387 ± 19.8μm，左眼（OS）为384 ± 20.2μm。右眼（OD）和左眼（OS）最薄点的角膜厚度分别为376 ± 20.2μm和370 ± 16.8μm。右眼和左眼最薄点与区域a之间均存在正相关（右眼：r = 0.892，P < 0.001；左眼：r = 0.832，P < 0.001）。
这是首次使用谱域AS - OCT在体内记录家兔角膜厚度。有色家兔角膜比人类角膜值薄近150μm。在本研究中，性别和眼别与中央角膜厚度的任何统计学差异均无关联。
