Qiu Yue, Gao Song, Ding Xiaoqiong, Lu Jie, Ji Xinya, Hao Wenli, Cheng Siqi, Du Haolinag, Gu Yajun, Yu Chenjie, Cheng Cheng, Gao Xia
Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Department of Otolaryngology-Head and Neck Surgery, Zhongda Hospital, Southeast University, Nanjing, 210008, China.
Neurosci Bull. 2025 Mar;41(3):421-433. doi: 10.1007/s12264-024-01326-8. Epub 2024 Dec 17.
Noise-induced hearing loss is a worldwide public health issue that is characterized by temporary or permanent changes in hearing sensitivity. This condition is closely linked to inflammatory responses, and interventions targeting the inflammatory gene tumor necrosis factor-alpha (TNFα) are known to mitigate cochlear noise damage. TNFα-induced proteins (TNFAIPs) are a family of translucent acidic proteins, and TNFAIP6 has a notable association with inflammatory responses. To date, there have been few reports on TNFAIP6 levels in the inner ear. To elucidate the precise mechanism, we generated transgenic mouse models with conditional knockout of Tnfaip6 (Tnfaip6 cKO). Evaluation of hair cell morphology and function revealed no significant differences in hair cell numbers or ribbon synapses between Tnfaip6 cKO and wild-type mice. Moreover, there were no notable variations in hair cell numbers or hearing function in noisy environments. Our results indicate that Tnfaip6 does not have a substantial impact on the auditory system.
噪声性听力损失是一个全球性的公共卫生问题，其特征是听力敏感度发生暂时或永久性变化。这种情况与炎症反应密切相关，已知针对炎症基因肿瘤坏死因子-α（TNFα）的干预措施可减轻耳蜗噪声损伤。TNFα诱导蛋白（TNFAIPs）是一类半透明酸性蛋白家族，TNFAIP6与炎症反应有显著关联。迄今为止，关于内耳中TNFAIP6水平的报道很少。为了阐明确切机制，我们构建了条件性敲除Tnfaip6（Tnfaip6 cKO）的转基因小鼠模型。对毛细胞形态和功能的评估显示，Tnfaip6 cKO小鼠与野生型小鼠之间的毛细胞数量或带状突触没有显著差异。此外，在嘈杂环境中，毛细胞数量或听力功能也没有明显变化。我们的结果表明，Tnfaip6对听觉系统没有实质性影响。
